Chavarro Jorge E, Rich-Edwards Janet W, Rosner Bernard A, Willett Walter C
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Fertil Steril. 2008 Mar;89(3):668-76. doi: 10.1016/j.fertnstert.2007.03.089. Epub 2007 Jul 10.
To examine whether use of multivitamins and intake of specific nutrients in multivitamins is associated with ovulatory infertility.
A prospective cohort study.
The Nurses' Health Study II.
PATIENT(S): Eighteen thousand five hundred fifty-five married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999.
INTERVENTION(S): None, observational study.
MAIN OUTCOME MEASURE(S): Incident reports of infertility caused by anovulation.
RESULT(S): During 8 years of follow-up, 438 women reported infertility caused by ovulatory disorder. There was an inverse association between frequency of multivitamin use and ovulatory infertility. The multivariate-adjusted relative risk (95% confidence interval) of ovulatory infertility was 0.88 (0.60, 1.28) for women consuming two tablets per week or less, 0.69 (0.51, 0.95) for women consuming three to five tablets per week, and 0.59 (0.46, 0.75) for women consuming six or more tablets per week, when compared with women who did not use these supplements (P, trend <.001). Folic acid appeared to explain part of the association between multivitamin supplement use and risk of ovulatory infertility.
CONCLUSION(S): Regular use of multivitamin supplements may decrease the risk of ovulatory infertility.
研究多种维生素的使用以及多种维生素中特定营养素的摄入量与排卵性不孕是否相关。
一项前瞻性队列研究。
护士健康研究II。
18555名已婚、绝经前且无不孕史的女性，她们在1991年至1999年间尝试怀孕或已怀孕。
无，观察性研究。
无排卵导致的不孕事件报告。
在8年的随访期间，438名女性报告了排卵障碍导致的不孕。多种维生素使用频率与排卵性不孕之间存在负相关。与未使用这些补充剂的女性相比，每周服用两片或更少片数多种维生素的女性，排卵性不孕的多变量调整相对风险（95%置信区间）为0.88（0.60，1.28）；每周服用三至五片的女性为0.69（0.51，0.95）；每周服用六片或更多片的女性为0.59（0.46，0.75）（P趋势<.001）。叶酸似乎可以解释多种维生素补充剂使用与排卵性不孕风险之间的部分关联。
定期使用多种维生素补充剂可能会降低排卵性不孕的风险。
