Budinger G R Scott, Sznajder Jacob I
Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
Clin Chest Med. 2006 Dec;27(4):655-69; abstract ix. doi: 10.1016/j.ccm.2006.06.007.
During acute lung injury (ALI), the alveolar-capillary barrier is damaged, resulting in the accumulation of fluid and protein in the alveolar space characteristic of the acute respiratory distress syndrome (ARDS). Disordered epithelial repair may contribute to the development of fibrosis and worsen outcomes in patients who have lung injury. This article discusses novel emerging therapies based on these mechanisms that are designed to preserve the function and promote the repair of the alveolar epithelium in patients who have ALI/ARDS.
在急性肺损伤（ALI）期间，肺泡-毛细血管屏障受损，导致急性呼吸窘迫综合征（ARDS）特征性的肺泡腔内液体和蛋白质积聚。上皮修复紊乱可能导致纤维化的发展，并使肺损伤患者的预后恶化。本文讨论基于这些机制的新型新兴疗法，这些疗法旨在保留功能并促进ALI/ARDS患者肺泡上皮的修复。
