葡糖醛酸木甘露聚糖与人类A549肺泡细胞中的CD14受体结合可诱导白细胞介素-8的产生。
Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production.
作者信息
Barbosa Fabiane M, Fonseca Fernanda L, Figueiredo Rodrigo T, Bozza Marcelo T, Casadevall Arturo, Nimrichter Leonardo, Rodrigues Marcio L
机构信息
Laboratório de Estudos Integrados em Bioquímica Microbiana, Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude (CCS), Rio de Janeiro, Brazil.
出版信息
Clin Vaccine Immunol. 2007 Jan;14(1):94-8. doi: 10.1128/CVI.00296-06. Epub 2006 Nov 8.
Abstract
Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.
摘要
葡糖醛酸木甘露聚糖（GXM）是新型隐球菌的主要荚膜多糖。GXM受体已在吞噬细胞和内皮细胞中得到表征，但识别该多糖的上皮分子仍不清楚。在本研究中，我们证明GXM与人II型肺泡上皮细胞中的CD14受体结合，导致促炎趋化因子白细胞介素-8的产生。
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