Fiaccadori F, Pedretti G, Ferrari C, Pizzaferri P, Riggio O, Orlandi N, Pezzarossa A
Infectious Diseases Department, University of Parma, Italy.
Dig Dis Sci. 1991 Jun;36(6):801-8. doi: 10.1007/BF01311240.
The behavior of insulin and glucagon and related metabolic substrates was assayed in plasma of patients with fulminant hepatic failure. All 12 subjects were provided the same nutritional support. High levels of insulin and glucagon were present at all times and no difference was observed between surviving patients (four) and those who died (8). Elevated values for branched-chain and aromatic amino acids as well as alanine were present. Statistically significant lower levels of aromatic amino acids and consequently a greater branched chain-aromatic amino acid ratio was found in surviving vs nonsurviving patients. A significantly greater level of alpha-fetoprotein was found in patients who survived as compared to those who died.
对暴发性肝衰竭患者的血浆中胰岛素、胰高血糖素及相关代谢底物的行为进行了测定。所有12名受试者均给予相同的营养支持。所有时间点均存在高水平的胰岛素和胰高血糖素，存活患者（4例）与死亡患者（8例）之间未观察到差异。支链氨基酸、芳香族氨基酸以及丙氨酸的值升高。在存活患者与未存活患者中，芳香族氨基酸水平在统计学上显著较低，因此支链-芳香族氨基酸比值更高。与死亡患者相比，存活患者的甲胎蛋白水平显著更高。
