Wilson R Alan, Ashton Peter D, Braschi Simon, Dillon Gary P, Berriman Matthew, Ivens Alasdair
Department of Biology, University of York, PO Box 373, York YO10 5YW, UK.
Trends Parasitol. 2007 Jan;23(1):14-20. doi: 10.1016/j.pt.2006.10.002. Epub 2006 Nov 13.
The recent release of version 3 of the Schistosoma mansoni genome assembly has made a wealth of information available to researchers. Here, progress made in schistosome genomics and post-genomics is considered. The current status of knowledge about the genome, transcriptome, proteome, glycome and immunome is summarized and recent publications briefly reviewed. The prospects for advances in understanding schistosome biology are highlighted. Most importantly, the limitations (which are mostly technical) that need to be addressed before the full potential of the genome database(s) can be realized are emphasized.
曼氏血吸虫基因组组装第3版的近期发布为研究人员提供了丰富的信息。在此,我们探讨了血吸虫基因组学和后基因组学所取得的进展。总结了目前关于基因组、转录组、蛋白质组、糖组和免疫组的知识现状,并简要回顾了近期的出版物。强调了在理解血吸虫生物学方面取得进展的前景。最重要的是,强调了在实现基因组数据库的全部潜力之前需要解决的局限性(大多是技术方面的)。