Tauman Riva, Gozal David
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep, Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Paediatr Respir Rev. 2006 Dec;7(4):247-59. doi: 10.1016/j.prrv.2006.08.003. Epub 2006 Oct 30.
The prevalence and severity of obesity in children and adolescent is dramatically increasing worldwide with a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving OSAS and metabolic and cardiovascular sequelae. Obstructive sleep apnea and obesity hypoventilation syndrome are important and serious consequences of obesity, and may in fact mediate components of the association between obesity and metabolic and cardiovascular morbidities, most likely via potentiation of inflammatory cascades. It is anticipated that the increased prevalence of obesity in children and adolescents in our society will be accompanied by a steady increase in the incidence of OSAS. In this review, we will examine our current understanding of sleep-disordered breathing and associated morbidities in obese children, and summarize the range of therapeutic modalities currently available for this high-risk population.
全球范围内，儿童和青少年肥胖的患病率及严重程度正急剧上升，与之相应的是肥胖相关疾病的患病率也在增加，尤其是那些涉及阻塞性睡眠呼吸暂停（OSAS）以及代谢和心血管后遗症的疾病。阻塞性睡眠呼吸暂停和肥胖低通气综合征是肥胖的重要且严重后果，实际上可能介导了肥胖与代谢和心血管疾病之间关联的部分机制，很可能是通过增强炎症级联反应来实现的。预计在我们社会中，儿童和青少年肥胖患病率的增加将伴随着OSAS发病率的稳步上升。在本综述中，我们将审视目前对肥胖儿童睡眠呼吸障碍及相关疾病的认识，并总结目前针对这一高危人群可用的治疗方式范围。
