Enck Paul, Kowalski Axel, Martens Ute, Klosterhalfen Sibylle
Department of Psychosomatic Medicine and Psychotherapy, University Hospitals Tübingen, Tübingen. Germany.
Eur J Gastroenterol Hepatol. 2006 Dec;18(12):1263-9. doi: 10.1097/01.meg.0000243879.25067.32.
We wished to determine the value of an open-access internet questionnaire for assessment of upper and lower gastrointestinal symptoms and health-related quality of life.
Between January 2002 and June 2005, a symptom scale for upper gastrointestinal and lower gastrointestinal symptoms was placed on a genuine website (www.gesundheits-umfrage.de) and linked to the website of the German irritable bowel syndrome patient group (www.Reizdarmselbsthilfe.de). Patients were asked to report gastrointestinal symptoms that had occurred during the last month. Patients who finished this symptoms questionnaire and acknowledged more than two of a total of eight upper gastrointestinal symptoms and/or more than two of 16 lower gastrointestinal symptoms were immediately offered the assessment of their health-related quality of life by a validated general quality of life scale--the patient general well-being inventory--a 22-item scale with six subscales (anxiety, depression, general well-being, self-control, health, and vitality) and a global scale. Total patient general well-being inventory scores and subscale values were correlated to upper gastrointestinal and lower gastrointestinal symptom scores including the Rome I definition of the irritable bowel syndrome, and to social variables.
Five thousand two hundred and fifty-six individuals completed symptom assessment. Out of these, 4431 had three or more upper gastrointestinal symptoms, the mean number of upper gastrointestinal symptoms reported was 3.2+/-2.0; 4456 had three or more lower gastrointestinal symptoms (mean: 10.3+/-3.3), and 3187 met the Rome I criteria for irritable bowel syndrome. A total of 3316 individuals completed the patient general well-being inventory assessment (1156 men, 2160 women, mean age: 37.7+/-12.3 years). Upper gastrointestinal, lower gastrointestinal, and total symptom score were higher in women than in men (P < 0.001), and significantly correlated to the global quality of life assessment. Family status affected the symptom scores (higher in singles) and quality of life scores (lower in people living in partnership for health, but higher for vitality and depression). Age correlated negatively with upper gastrointestinal, lower gastrointestinal, and with total symptom scores as well as with some patient general well-being inventory scores.
Symptom and quality of life assessment using an open internet questionnaire is feasible and generates data which are, in large, comparable to those from other sources of assessment, despite the fact that the population addressed is, on average, moderately younger than previously studied cohorts.
我们希望确定一份开放式互联网问卷对于评估上、下消化道症状及健康相关生活质量的价值。
在2002年1月至2005年6月期间，一份关于上消化道和下消化道症状的症状量表被放置在一个真实的网站（www.gesundheits-umfrage.de）上，并与德国肠易激综合征患者组织的网站（www.Reizdarmselbsthilfe.de）相链接。要求患者报告过去一个月内出现的胃肠道症状。完成该症状问卷且在上消化道总共八项症状中认可两项以上及/或在下消化道16项症状中认可两项以上的患者，会立即被提供通过一份经过验证的一般生活质量量表——患者总体幸福感量表——进行健康相关生活质量的评估。该量表有22个项目，包含六个子量表（焦虑、抑郁、总体幸福感、自我控制、健康和活力）以及一个总体量表。患者总体幸福感量表的总分及子量表分值与上消化道和下消化道症状评分（包括肠易激综合征的罗马I标准）以及社会变量相关。
5256人完成了症状评估。其中，4431人有三项或更多上消化道症状，报告的上消化道症状平均数量为3.2±2.0；4456人有三项或更多下消化道症状（平均：10.3±3.3），3187人符合肠易激综合征的罗马I标准。共有3316人完成了患者总体幸福感量表评估（1156名男性，2160名女性，平均年龄：37.7±12.3岁）。女性的上消化道、下消化道及总症状评分高于男性（P<0.001），且与总体生活质量评估显著相关。家庭状况影响症状评分（单身者较高）和生活质量评分（处于健康伴侣关系中的人总体生活质量较低，但活力和抑郁方面较高）。年龄与上消化道、下消化道及总症状评分以及一些患者总体幸福感量表评分呈负相关。
使用开放式互联网问卷进行症状和生活质量评估是可行的，并且能产生与其他评估来源在很大程度上可比的数据，尽管所涉及的人群平均而言比之前研究的队列稍年轻。
