Gupta Swati, Singh Sarman
Division of Clinical Microbiology, Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
World J Gastroenterol. 2006 Nov 14;12(42):6879-83. doi: 10.3748/wjg.v12.i42.6879.
To determine the prevalence of hepatitis B and C virus infections in human immunodeficiency virus (HIV) -positive patients at a tertiary care hospital in New Delhi, India.
Serum samples from 451 HIV positive patients were analyzed for HBsAg and HCV antibodies during three years (Jan 2003-Dec 2005). The control group comprised of apparently healthy bone-marrow and renal donors.
The study population comprised essentially of heterosexually transmitted HIV infection. The prevalence rate of HBsAg in this population was 5.3% as compared to 1.4% in apparently healthy donors (P < 0.001). Though prevalence of HCV co-infection (2.43%) was lower than HBV in this group of HIV positive patients, the prevalence was significantly higher (P < 0.05) than controls (0.7%). Triple infection of HIV, HBV and HCV was not detected in any patient.
Our study shows a significantly high prevalence of hepatitis virus infections in HIV infected patients. Hepatitis viruses in HIV may lead to faster progression to liver cirrhosis and a higher risk of antiretroviral therapy induced hepatotoxicity. Therefore, it would be advisable to detect hepatitis virus co-infections in these patients at the earliest.
确定印度新德里一家三级护理医院中人类免疫缺陷病毒（HIV）阳性患者的乙型和丙型肝炎病毒感染率。
在三年期间（2003年1月至2005年12月）对451例HIV阳性患者的血清样本进行乙肝表面抗原（HBsAg）和丙肝抗体分析。对照组由表面健康的骨髓和肾脏供体组成。
研究人群主要为通过异性传播感染HIV。该人群中HBsAg的感染率为5.3%，而在表面健康的供体中为1.4%（P<0.001）。虽然在这组HIV阳性患者中丙肝合并感染率（2.43%）低于乙肝感染率，但该感染率显著高于对照组（0.7%）（P<0.05）。未在任何患者中检测到HIV、HBV和HCV的三重感染。
我们的研究表明HIV感染患者中肝炎病毒感染率显著较高。HIV患者感染肝炎病毒可能导致更快进展为肝硬化以及抗逆转录病毒治疗引起肝毒性的风险更高。因此，尽早检测这些患者中的肝炎病毒合并感染是可取的。
