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1型糖尿病的移植治疗:全胰腺和胰岛细胞移植。

Transplantation for type 1 diabetes: whole organ pancreas and islet cells.

作者信息

Pavlakis Martha, Khwaja Khalid

机构信息

Beth Israel Deaconess Medical Center, The Transplant Center, 110 Francis Street, 7th Floor, Boston, MA 02215, USA.

出版信息

Curr Diab Rep. 2006 Dec;6(6):473-8. doi: 10.1007/s11892-006-0082-z.

DOI:10.1007/s11892-006-0082-z
PMID:17118232
Abstract

Beta-cell transplantation can be either a whole organ pancreas transplant or an islet cell transplant; both have resulted in restoration of a normoglycemic state. These transplants can be performed in conjunction with kidney transplants or as solitary grafts. In general, whole organ transplants have more sustained and durable function and are more widely available than their islet counterparts, but entail a much more invasive procedure. Beta-cell transplantation continues to evolve, with considerable improvement in results over the past two decades, and is a cost-effective option for select patients with type 1 diabetes.

摘要

β细胞移植可以是全器官胰腺移植或胰岛细胞移植;两者都能使血糖恢复正常。这些移植可以与肾移植同时进行,也可以作为单独的移植。一般来说,全器官移植的功能更持久、更耐用,而且比胰岛移植更容易获得,但需要更具侵入性的手术。β细胞移植仍在不断发展,在过去二十年中取得了显著的成果改善,对于特定的1型糖尿病患者来说是一种具有成本效益的选择。

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2
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XIAP gene expression protects β-cells and human islets from apoptotic cell death.XIAP 基因表达可保护β细胞和人胰岛免受细胞凋亡。
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本文引用的文献

1
Current indications for pancreas or islet transplant.胰腺或胰岛移植的当前适应症。
Diabetes Obes Metab. 2006 Jan;8(1):1-7. doi: 10.1111/j.1463-1326.2004.00460.x.
2
Impairment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen.单独胰岛移植或肾后胰岛移植后使用西罗莫司/他克莫司免疫抑制方案导致的肾功能损害。
Transpl Int. 2005 Nov;18(11):1226-30. doi: 10.1111/j.1432-2277.2005.00194.x.
3
Superior long-term results of simultaneous pancreas-kidney transplantation from pediatric donors.
小儿供体胰肾联合移植的长期卓越效果。
Am J Transplant. 2004 Dec;4(12):2093-101. doi: 10.1046/j.1600-6143.2004.00599.x.
4
Mortality assessment for pancreas transplants.胰腺移植的死亡率评估。
Am J Transplant. 2004 Dec;4(12):2018-26. doi: 10.1111/j.1600-6143.2004.00667.x.
5
The effect of center volume on pancreas transplant outcomes.中心容量对胰腺移植结果的影响。
Surgery. 2004 Aug;136(2):225-31. doi: 10.1016/j.surg.2004.04.023.
6
Prevalence of hepatic steatosis after islet transplantation and its relation to graft function.胰岛移植后肝脂肪变性的患病率及其与移植物功能的关系。
Diabetes. 2004 May;53(5):1311-7. doi: 10.2337/diabetes.53.5.1311.
7
Decline in native renal function early after bladder-drained pancreas transplantation alone.单纯膀胱引流式胰腺移植术后早期肾功能减退。
Transplantation. 2004 Mar 27;77(6):844-9. doi: 10.1097/01.tp.0000114607.62534.c9.
8
Pancreas transplantation in type 1 diabetes.1型糖尿病的胰腺移植
Diabetes Care. 2004 Jan;27 Suppl 1:S105. doi: 10.2337/diacare.27.2007.s105.
9
Survival after pancreas transplantation in patients with diabetes and preserved kidney function.糖尿病且肾功能保留患者胰腺移植后的生存情况。
JAMA. 2003 Dec 3;290(21):2817-23. doi: 10.1001/jama.290.21.2817.
10
Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients.单纯胰腺移植可使1型糖尿病患者的心血管危险因素和心脏功能早期得到改善。
Transplantation. 2003 Sep 27;76(6):974-6. doi: 10.1097/01.TP.0000084202.18999.1D.