Rosselli Sergio, Maggio Antonella, Bellone Gabriella, Formisano Carmen, Basile Adriana, Cicala Carla, Alfieri Alessio, Mascolo Nicola, Bruno Maurizio
Dipartimento di Chimica Organica, Università degli Studi di Palermo, Palermo, Italy.
Planta Med. 2007 Feb;73(2):116-20. doi: 10.1055/s-2006-951772. Epub 2006 Nov 24.
The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 microg/mL), the most active being imperatorin (3) (MICs between 32 and 128 microg/mL) and citropten (4) (MICs between 16 and 256 microg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.
对绒毛马吉达里斯（Magydaris tomentosa (Desf.) DC）花朵的丙酮提取物和甲醇提取物进行植物化学研究，得到了六种已知的香豆素以及（+）-水合橙皮内酯（7），此前未曾报道其为天然产物。测试了伞形花内酯（1）、蛇床子素（2）、欧前胡素（3）、柑橘黄酮（4）和（+）-水合橙皮内酯（7）对革兰氏阳性菌和革兰氏阴性菌的抗菌活性。本研究中分离得到的所有香豆素（1-7）均抑制了所有测试菌株的生长（最低抑菌浓度在16至256微克/毫升之间），其中活性最强的是欧前胡素（3）（最低抑菌浓度在32至128微克/毫升之间）和柑橘黄酮（4）（最低抑菌浓度在16至256微克/毫升之间）。还评估了化合物1-4和7的抗凝活性。
