Jackson Jadin C, Johnson Adam, Redish A David
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA.
J Neurosci. 2006 Nov 29;26(48):12415-26. doi: 10.1523/JNEUROSCI.4118-06.2006.
Hippocampal firing patterns during behavior are reactivated during rest and subsequent slow-wave sleep. These reactivations occur during transient local field potential (LFP) events, termed sharp waves. Theories of hippocampal processing suggest that sharp waves arise from strengthened plasticity, and that the strengthened plasticity depends on repeated cofiring of pyramidal cells. We tested these predictions by recording neural ensembles and LFPs from rats running tasks requiring different levels of behavioral repetition. The number of sharp waves emitted increased during sessions with more regular behaviors. Reactivation became more similar to behavioral firing patterns across the session. This enhanced reactivation also depended on the regularity of the behavior. Additional studies in CA3 and CA1 found that the number of sharp waves emitted also increased in CA3 recordings as well as CA1, but that the time courses were different between the two structures.
行为过程中的海马体放电模式在休息和随后的慢波睡眠期间会重新激活。这些重新激活发生在短暂的局部场电位（LFP）事件期间，即尖波。海马体处理理论表明，尖波源于增强的可塑性，而增强的可塑性取决于锥体细胞的重复共同放电。我们通过记录大鼠执行需要不同行为重复水平任务时的神经集群和局部场电位来检验这些预测。在行为更规律的实验时段中，发出的尖波数量增加。在整个实验时段内，重新激活变得与行为放电模式更加相似。这种增强的重新激活也取决于行为的规律性。在CA3和CA1区域的额外研究发现，CA3记录以及CA1记录中发出的尖波数量也增加了，但两个结构之间的时间进程不同。
