Ermolaev V I, Mirtskhulava Z G, Savina M A, Gorelov I G, Matichashvili R S, Varanov O K
Genetika. 1991 Feb;27(2):304-15.
The 5 alpha-macroglobulin allotypes alpha M1, alpha M2, alpha M3, alpha M4 and alpha M5 were identified in pig. The alpha M1 allotype was reported as a marker of pig alpha-macroglobulin, the latter being homologous to alpha 2-macroglobulins in human and in mink. The allotypes alpha M2-alpha M5 were specified as markers of the second isotypical variant of pig alpha-macroglobulins, which was homologous to mink Lpm macroglobulin (alpha 1M). As seen from data obtained by International Comparative Test ISABR 87-88, alpha M1 is a new allotype, while allotypes alpha M2--alpha M5 correspond to four allotypes in the Gp system (Janik et al.). Based on these data, a conclusion was made on the homology between the Lpm system in american mink and the Gp system in pig. Since the allotypes studied are the part of alpha-macroglobulins, a locus controlling them was designated the AM locus. We also find it more advantageous to apply the same name to the homologous locus in mink, instead of the Lpm used earlier. Genetic control of 5 allotypes was studied and the structure of the AM locus in pig analysed in detail. Comparative study of organization of the above locus and the homologous locus in mink was carried out.
在猪中鉴定出了5种α-巨球蛋白同种异型，即αM1、αM2、αM3、αM4和αM5。αM1同种异型被报道为猪α-巨球蛋白的一个标记，后者与人及水貂的α2-巨球蛋白同源。αM2-αM5同种异型被指定为猪α-巨球蛋白第二种同型变体的标记，该变体与水貂Lpm巨球蛋白（α1M）同源。从国际比较试验ISABR 87 - 88获得的数据可以看出，αM1是一种新的同种异型，而αM2-αM5同种异型对应于Gp系统中的四种同种异型（亚尼克等人）。基于这些数据，得出了美洲水貂的Lpm系统与猪的Gp系统之间存在同源性的结论。由于所研究的同种异型是α-巨球蛋白的一部分，因此将控制它们的基因座命名为AM基因座。我们还发现，将水貂中同源基因座使用相同的名称，而不是先前使用的Lpm，更为有利。研究了5种同种异型的遗传控制，并详细分析了猪中AM基因座的结构。对上述基因座与水貂中同源基因座的组织进行了比较研究。
