Shumnyĭ T V, Ermolaev V I, Miroshnichenko S M, Baranov O K
Genetika. 1989 Mar;25(3):513-20.
The data on interspecific distribution and antigenic variability of homologues of mink Lpm-protein (Lpm) and alpha 2M-globulin (alpha 2M) among 43 species of 6 orders of mammals are presented. Strong variability of antigenic structure of Lpm and alpha 2M of Rodentia and Artiodactyla orders was established. This fact allows to classify the macroglobulins studied as belonging to the group of evolutionary high-speed plasma globulins. In the plasma of human and green marmoset (Cercopithecus aephiops) the only homologue of alpha 2M was found. The lack of reaction to Lpm in above-mentioned species allows to postulate significant differences between Carnivora and Primates in the organization of this gene cluster. Unique features of antigenic variability of Lpm and alpha 2M were also fixed among other systematical groups tested. Taken together, the data obtained stimulate scientific interest to the study of molecular organization of the Lpm and alpha 2M gene families.
本文展示了在6目43种哺乳动物中貂Lpm蛋白（Lpm）和α2M球蛋白（α2M）同源物的种间分布及抗原变异性数据。已确定啮齿目和偶蹄目动物的Lpm和α2M抗原结构具有很强的变异性。这一事实使得所研究的巨球蛋白可归类为进化上高速血浆球蛋白组别。在人和绿狨猴（Cercopithecus aephiops）血浆中仅发现α2M的同源物。上述物种对Lpm无反应，这使得我们可以推测食肉目和灵长目在该基因簇组织方面存在显著差异。在其他受试分类群中也确定了Lpm和α2M抗原变异的独特特征。综上所述，所获得的数据激发了对Lpm和α2M基因家族分子组织研究的科学兴趣。
