体外培养的亲胸腺辐射白血病病毒对淋巴细胞的体外感染。
In vitro infection of lymphoid cells by thymotropic radiation leukemia virus grown in vitro.
作者信息
Haas M, Hilgers J
出版信息
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3546-50. doi: 10.1073/pnas.72.9.3546.
Abstract
Murine lymphoid cells were infected in vitro with purified leukemogenic radiation leukemia virus (RadLV) produced by virus-induced lymphoblast cell lines. Thymocytes were shown to be highly susceptible to infection by the virus, whereas murine or other fibroblasts were refractory to it. Murine bone marrow and spleen cells were shown to be much less sensitive to infection by this thymotropic RadLV. By comparison, a B-tropic RadLV isolate (RadLV), propagated on a mouse fibroblast cell line, was noninfectious for lymphoid cells but infected fibroblasts. A correlation was shown to exist between in vitro infection of thymocytes, as assayed by immunofluorescence, and in vivo leukemogenicity of the thymotropic RadLV. This constitutes a rapid in vitro test for in vivo leukemogenicity of a natural lymphatic leukemia virus.
摘要
用病毒诱导的淋巴母细胞系产生的纯化致白血病辐射白血病病毒（RadLV）在体外感染小鼠淋巴细胞。结果显示，胸腺细胞对该病毒高度敏感，而小鼠或其他成纤维细胞则对其具有抗性。已证明小鼠骨髓和脾细胞对这种嗜胸腺RadLV的感染敏感性要低得多。相比之下，在小鼠成纤维细胞系上繁殖的嗜B淋巴细胞RadLV分离株（RadLV）对淋巴细胞无感染性，但可感染成纤维细胞。通过免疫荧光测定，体外感染胸腺细胞与嗜胸腺RadLV的体内致白血病性之间存在相关性。这构成了一种对天然淋巴白血病病毒体内致白血病性的快速体外检测方法。
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