辐射白血病病毒的生物学和血清学特性
Biological and serological characterization of radiation leukemia virus.
作者信息
Declève A, Lieberman M, Ihle J N, Kaplan H S
出版信息
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4675-9. doi: 10.1073/pnas.73.12.4675.
Abstract
Radiation leukemia virus, isolated from radiation-induced lymphomas in C57BL/Ka mice and propagated in that strain, is thymotropic and leukemogenic in vivo but replicates poorly, if at all, in mouse and mink fibroblast cultures in vitro. Comparative studies indicate that this naturally occurring virus is distinct from the previously recognized classes of endogenous murine ecotropic and xenotropic C-type viruses which are capable of replication on fibroblasts (fibrotropic) but are neither thymotropic nor leukemogenic. These studies also demonstrate that a differentiation-specific restriction system governing the replication of the murine ecotropic C-type viruses operates in addition to the previously defined Fv-1 and SRV gene restriction systems.
摘要
从C57BL/Ka小鼠辐射诱导的淋巴瘤中分离出来并在该品系中传代的辐射白血病病毒，在体内具有嗜胸腺性和致白血病性，但在体外小鼠和貂成纤维细胞培养物中复制能力很差，甚至根本不复制。比较研究表明，这种天然存在的病毒不同于先前公认的内源性鼠嗜亲性和异嗜性C型病毒类别，后者能够在成纤维细胞上复制（嗜纤维性），但既无嗜胸腺性也无致白血病性。这些研究还表明，除了先前定义的Fv-1和SRV基因限制系统外，还有一个控制鼠嗜亲性C型病毒复制的分化特异性限制系统在起作用。
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本文引用的文献
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Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice.小鼠辐射诱导淋巴肿瘤滤液的致白血病活性。
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Selective thymic localization of murine leukemia virus-related antigens in C57BL-Ka mice after inoculation with radiation virus.用辐射病毒接种后，C57BL-Ka小鼠中鼠白血病病毒相关抗原的选择性胸腺定位
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Widespread natural occurrence of high titers of neutralizing antibodies to a specific class of endogenous mouse type-C virus.广泛自然存在针对一类特定内源性小鼠C型病毒的高滴度中和抗体。
Proc Natl Acad Sci U S A. 1974 May;71(5):1957-61. doi: 10.1073/pnas.71.5.1957.
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Autogenous immunity to endogenous RNA tumor virus. Identification of antibody reactivity to select viral antigens.对内源性RNA肿瘤病毒的自身免疫。对选定病毒抗原的抗体反应性鉴定。
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An improved murine leukemia virus immunofluorescence assay.一种改进的鼠白血病病毒免疫荧光测定法。
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Xenotropic viruses: murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains.嗜异性病毒：与美国国立卫生研究院瑞士小鼠、新西兰黑小鼠及其他小鼠品系相关的鼠白血病病毒。
Science. 1973 Dec 14;182(4117):1151-3. doi: 10.1126/science.182.4117.1151.
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Adaptation of plaque assay methods to the in vitro quantitation of the radiation leukemia virus.将噬斑测定方法应用于辐射白血病病毒的体外定量分析。
J Virol. 1973 Jul;12(1):68-73. doi: 10.1128/JVI.12.1.68-73.1973.
10
Continuous propagation of radiation leukemia virus on a C57BL mouse-embryo fibroblast line, with attenuation of leukemogenic activity.辐射白血病病毒在C57BL小鼠胚胎成纤维细胞系上的持续传代，同时白血病生成活性减弱。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1250-3. doi: 10.1073/pnas.70.4.1250.
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