Li X-M
School of Food Engineering of XingJang Agriculture College, Urumqi city, XinJiang 832000, PR China.
Int J Biol Macromol. 2007 Apr 10;40(5):461-5. doi: 10.1016/j.ijbiomac.2006.11.002. Epub 2006 Nov 17.
Fruit from Lycium barbarum L. in the family Solanaceae is well-known in traditional Chinese herbal medicine. Lycium barbarum polysaccharides (LBP) have been identified as one of the active ingredients responsible for its biological activities. We isolated polysaccharides from dried Lycium barbarum fruits by boiling water extraction. In the study, 50 animals were divided into two groups: a nondiabetic control (n=10) and a diabetic group (n=40). Diabetes was induced by a single injection of streptozotocin (50mg/kg BW; Sigma, USA) freshly dissolved in a 0.1 mol/L citrate buffer (pH 4.5) into the intraperitonium. The normal control rats and the untreated diabetic control rats were only injected with the citrate buffer. Treated diabetic rats were administrated with LBP in drinking water through oral gavage for 30 days. At the end of experiment, oxidative indice in blood, liver and kidney of all groups were examined. The results show that administration of LBP can restore abnormal oxidative indice near normal levels. Therefore, we may assume that LBP is effective in the protection of liver and kidney tissue from the damage of STZ-induced diabetic rats and that the LBP may be of use as a antihyperglycemia agent.
茄科枸杞属植物枸杞的果实是传统中草药中广为人知的。枸杞多糖（LBP）已被确定为其具有生物活性的有效成分之一。我们通过沸水提取从干燥的枸杞果实中分离出多糖。在该研究中，50只动物被分为两组：非糖尿病对照组（n = 10）和糖尿病组（n = 40）。通过将新鲜溶解于0.1mol/L柠檬酸盐缓冲液（pH 4.5）中的链脲佐菌素（50mg/kg体重；美国西格玛公司）单次腹腔注射诱导糖尿病。正常对照大鼠和未治疗的糖尿病对照大鼠仅注射柠檬酸盐缓冲液。经治疗的糖尿病大鼠通过口服灌胃在饮用水中给予LBP 30天。在实验结束时，检测所有组血液、肝脏和肾脏中的氧化指标。结果表明，给予LBP可使异常氧化指标恢复至接近正常水平。因此，我们可以推测LBP在保护肝脏和肾脏组织免受链脲佐菌素诱导的糖尿病大鼠损伤方面是有效的，并且LBP可能用作抗高血糖剂。
