从非致病性分枝杆菌中提取的一种组分对小鼠同基因肿瘤免疫的增强作用。
Enhancement of immunity against murine syngeneic tumors by a fraction extracted from non-pathogenic mycobacteria.
作者信息
Lamensans A, Chedid L, Lederer E, Rosselet J P, Gustafson R H, Spencer H J, Ludwig B, Berger F M
出版信息
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3656-60. doi: 10.1073/pnas.72.9.3656.
Abstract
The data reported here demonstrate that a preparation extracted from nonpathogenic mycobacteria such as Mycobacterium smegmatis and hereafter referred to as interphase material protected mice against Ehrlich ascitic carcinoma, L-1210 leukemia, and another syngeneic lymphoid leukemia. Furthermore, mice treated by this preparation were much less susceptible to endotoxins than when stimulated by BCG (bacillus Calmette-Guerin) or M. smegmatis cells. Moreover, guinea pigs treated by interphase material administered in Freund's incomplete adjuvant showed an increased immune response, yet their sensitivity to tuberculin was much weaker than that of controls sensitized with Freund's complete adjuvant. Finally, resistance to Columbia SK virus infection could be demonstrated when interphase material was administered to mice prior to virus challenge.
摘要
此处报告的数据表明，从非致病性分枝杆菌（如耻垢分枝杆菌）中提取的一种制剂（以下称为间期物质）可保护小鼠免受艾氏腹水癌、L-1210白血病和另一种同基因淋巴细胞白血病的侵害。此外，用该制剂处理的小鼠比用卡介苗（卡介苗）或耻垢分枝杆菌细胞刺激时对内毒素的敏感性要低得多。此外，用弗氏不完全佐剂给予间期物质处理的豚鼠显示出免疫反应增强，但其对结核菌素的敏感性比用弗氏完全佐剂致敏的对照组弱得多。最后，当在病毒攻击前给小鼠施用间期物质时，可以证明其对哥伦比亚SK病毒感染具有抵抗力。
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本文引用的文献
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Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6'-Dimycolate) in Tumor Regression.非活卡介苗和分枝杆菌衍生成分的癌症免疫治疗：cord 因子（海藻糖-6,6'-二没食子酸酯）在肿瘤消退中的作用。
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Sensitivity of mice to endotoxin after vaccination with BCG (Bacillus Calmette-Guérin).卡介苗（Bacillus Calmette-Guérin）接种后小鼠对内毒素的敏感性。
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