Islam S K Nazrul, Ahmed Luthfor, Khan Md Nazrul Islam, Huque Saiful, Begum Anwara, Yunus Abul Bashar Mohammed
Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
Pediatr Int. 2006 Dec;48(6):543-8. doi: 10.1111/j.1442-200X.2006.02291.x.
Colostrum is the first defense for neonates. It is rich in immune components including immunoglobulins and viable immune cells. In the present study, human colostrum collected from 105 postpartum mothers was analyzed for its IgA, IgM, IgG levels, and peripheral immune cells.
Enzyme-linked immunosorbent assay was used to analyze the serum immunoglobulin concentrations. Immune cells were estimated by counting 200 cells.
IgA was the dominant immunoglobulin and ranged from 2.84 to 8.69 g/L (mean 5.61 g/L). Mean IgM and IgG concentrations were 0.4 g/L (0.16-0.66 g/L) and 0.095 g/L (0.04-0.15 g/L), respectively. Neutrophil-macrophage (neu-mac) predominated in cell count (59%) followed by lymphocyte-plasma cells (lymph-plasma; 40%). The influence of maternal nutritional status, age, parity and income levels on the colostral immunological factors was studied. No significant association could be traced for immunoglobulin content, suggesting that maternal characteristics do not have any bearing on the immunoglobulin content of colostrum. Mean value of eosinophils was found to be higher among the underweight than the normal mothers (F= 3.143, r=-0.101). Maternal age was positively correlated with eosinophil (F= 3.296, r= 0.162). Concentration of neu-mac had a positive significant correlation with parity (t=-2.07, r= 0.205), while it was negatively significant for lymphocyte-plasma cells (t= 2.073, r=-0.101). However, the correlation coefficients of the immunologic parameters with other maternal characteristics were statistically insignificant.
Colostrum has enough humoral and cellular elements to protect babies. Therefore, immune protection derived from breastfeeding depends on the immunoglobulin level of the colostrum as well as the amount of colostrum ingested.
初乳是新生儿的第一道防线。它富含免疫成分，包括免疫球蛋白和活的免疫细胞。在本研究中，对从105名产后母亲收集的人初乳进行了IgA、IgM、IgG水平及外周免疫细胞分析。
采用酶联免疫吸附测定法分析血清免疫球蛋白浓度。通过计数200个细胞来估计免疫细胞。
IgA是主要的免疫球蛋白，范围为2.84至8.69 g/L（平均5.61 g/L）。IgM和IgG的平均浓度分别为0.4 g/L（0.16 - 0.66 g/L）和0.095 g/L（0.04 - 0.15 g/L）。中性粒细胞 - 巨噬细胞（neu - mac）在细胞计数中占主导（59%），其次是淋巴细胞 - 浆细胞（lymph - plasma；40%）。研究了母亲营养状况、年龄、胎次和收入水平对初乳免疫因素的影响。未发现免疫球蛋白含量有显著关联，表明母亲特征与初乳免疫球蛋白含量无关。发现体重过轻的母亲中嗜酸性粒细胞的平均值高于正常母亲（F = 3.143，r = -0.101）。母亲年龄与嗜酸性粒细胞呈正相关（F = 3.296，r = 0.162）。neu - mac的浓度与胎次呈显著正相关（t = -2.07，r = 0.205），而与淋巴细胞 - 浆细胞呈显著负相关（t = 2.073，r = -0.101）。然而，免疫参数与其他母亲特征的相关系数在统计学上无显著意义。
初乳具有足够的体液和细胞成分来保护婴儿。因此，母乳喂养提供的免疫保护取决于初乳的免疫球蛋白水平以及摄入的初乳量。
