来源于轮伞沙参的细胞毒贝壳杉烷二萜。

Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

Phytochemistry. 2009 Jul-Aug;70(11-12):1462-6. doi: 10.1016/j.phytochem.2009.07.037. Epub 2009 Aug 25.

DOI:10.1016/j.phytochem.2009.07.037

PMID:19712947

Abstract

Five (1-5) ent-kaurane diterpenoids and 17 other known ones, were isolated from the leaves and stems of Isodon sinuolata. Their structures were determined on the basis of spectroscopic methods including 1D and 2D NMR spectroscopic analysis. All compounds were evaluated for cytotoxicity against a small panel of cell lines. Some compounds exhibited significant cytotoxicity.

摘要

从 Isodon sinuolata 的叶和茎中分离得到五个（1-5）ent-kaurane 二萜类化合物和 17 个其他已知化合物。根据包括 1D 和 2D NMR 光谱分析在内的光谱方法确定了它们的结构。所有化合物均针对小细胞系进行了细胞毒性评估。一些化合物表现出显著的细胞毒性。