一种含罕见环戊二烯基阴离子单元的两性离子生物碱，从虎皮楠的茎皮中提取得到。

A zwitterionic alkaloid, containing a rare cyclopentadienyl anion unit, from the stem barks of Daphniphyllum macropodum Miq.

作者信息

Gan Xian-Wen, Bai Hai-Yun, Chen Qi-Gang, Ma Lei, Hu Li-Hong

机构信息

Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P.R. China.

出版信息

Chem Biodivers. 2006 Nov;3(11):1255-9. doi: 10.1002/cbdv.200690127.

DOI:10.1002/cbdv.200690127

PMID:17193239

Abstract

A new Daphniphyllum alkaloid daphnicyclidin L (1), containing a rare cyclopentadienyl anion, which is stabilized as a zwitterion by an internal iminium counterion, was isolated from the stem barks of Daphniphyllum macropodum Miq., together with four known alkaloids: daphnicyclidin D (2), daphnicyclidin H (3), deoxyyuzurimine (4), and yuzurimine (5). The structures were elucidated on the basis of spectroscopic data. The configuration of 1 was elucidated by single-crystal X-ray diffraction crystallography.

摘要

从交让木（Daphniphyllum macropodum Miq.）的茎皮中分离得到一种新的交让木生物碱——交让环定碱L（1），其含有一个罕见的环戊二烯基阴离子，该阴离子通过内部亚胺离子抗衡离子以两性离子形式稳定存在，同时还分离得到了四种已知生物碱：交让环定碱D（2）、交让环定碱H（3）、脱氧乌苏里明（4）和乌苏里明（5）。结构通过光谱数据得以阐明。1的构型通过单晶X射线衍射晶体学得以阐明。