大瓣芹素 K-O，大瓣芹中的生物碱。

Daphmacromines K-O, alkaloids from Daphniphyllum macropodum.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.

出版信息

Fitoterapia. 2013 Sep;89:205-9. doi: 10.1016/j.fitote.2013.06.005. Epub 2013 Jun 10.

DOI:10.1016/j.fitote.2013.06.005

PMID:23756191

Abstract

Five new yuzurimine-type Daphniphyllum alkaloids, daphmacromines K-O (1-5), were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. Daphmacromine O (5) showed moderate cytotoxic activity against brine shrimp.

摘要

从大瓣叶(Daphniphyllum macropodum)的叶和茎中分离得到五个新的紫杉烷型千金藤堿类化合物，分别命名为 daphmacromines K-O（1-5）。通过二维 NMR 光谱和质谱等广泛的光谱技术阐明了它们的结构。化合物 daphmacromine O（5）对卤虫表现出中等的细胞毒性。