评估含或不含烟草的槟榔咀嚼者口腔黏膜细胞微核频率作为遗传毒性损伤标志物的情况。

Evaluation of frequency of micronucleated oral mucosa cells as a marker for genotoxic damage in chewers of betel quid with or without tobacco.

作者信息

Nair U, Obe G, Nair J, Maru G B, Bhide S V, Pieper R, Bartsch H

机构信息

International Agency for Research on Cancer, Lyon, France.

出版信息

Mutat Res. 1991 Nov;261(3):163-8. doi: 10.1016/0165-1218(91)90063-r.

DOI:10.1016/0165-1218(91)90063-r

PMID:1719407

Abstract

The frequency of micronucleated cells (MNC) derived from exfoliated human oral mucosal cells has been measured to assess genotoxic damage in chewers of betel quid with tobacco (BQT) and tobacco with lime (T). Significantly elevated frequencies of MNC were observed in the exposed groups (BQT = 4.83 +/- 0.70; T = 5.20 +/- 0.66 per 1000 cells) compared to the control group (C = 2.59 +/- 0.37) although the levels observed were lower than those reported in the literature. No correlation was seen between age, duration and frequency of habits and the frequency of MNC in the 2 habit groups. Clastogenic agents in betel quid possibly involved in micronucleus formation are discussed.

摘要

通过测量来自人脱落口腔黏膜细胞的微核细胞（MNC）频率，以评估嚼含烟草的槟榔（BQT）和含石灰的烟草（T）者的遗传毒性损伤。与对照组（C = 2.59 +/- 0.37）相比，暴露组（BQT = 每1000个细胞4.83 +/- 0.70；T = 5.20 +/- 0.66）的MNC频率显著升高，尽管观察到的水平低于文献报道。在这两个习惯组中，未发现年龄、习惯持续时间和频率与MNC频率之间存在相关性。讨论了槟榔中可能参与微核形成的致断裂剂。