Kim Mi-Ja, Lee Hee Jae, Wiryowidagdo Sumali, Kim Hye Kyung
Department of Obesity Management, Graduated School of Obesity Science, Dongduk Women's University, Seoul, Republic of Korea.
J Med Food. 2006 Winter;9(4):587-90. doi: 10.1089/jmf.2006.9.587.
Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compared with SHR rats not given GPE (P < .05). Furthermore, GPE-administered rats had significantly lower serum lactate dehydrogenase, creatine phosphate kinase, and increased nitric oxide (NO), a known vasodilator, compared with the non-GPE-administered SHR group (P < .05). These results suggest that oral administration of aqueous GPE may be useful for prevention and treatment of hypertension through increasing NO production in blood vessels.
将平卧菊三七（Gynura procumbens (Lour.) Merr.）的水提取物对自发性高血压（SHR）大鼠进行口服给药4周，并测定其降压效果。与未给予平卧菊三七提取物（GPE）的SHR大鼠相比，口服500 mg/kg平卧菊三七提取物（GPE）可使SHR大鼠的血压显著降低（P < 0.05）。此外，与未给予GPE的SHR组相比，给予GPE的大鼠血清乳酸脱氢酶、肌酸磷酸激酶显著降低，而作为已知血管舒张剂的一氧化氮（NO）水平升高（P < 0.05）。这些结果表明，口服平卧菊三七水提取物可能通过增加血管中NO的生成来预防和治疗高血压。
