人体肠道细菌对亚油酸的代谢：共轭亚油酸生物合成的不同途径。
Metabolism of linoleic acid by human gut bacteria: different routes for biosynthesis of conjugated linoleic acid.
作者信息
Devillard Estelle, McIntosh Freda M, Duncan Sylvia H, Wallace R John
机构信息
Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, United Kingdom.
出版信息
J Bacteriol. 2007 Mar;189(6):2566-70. doi: 10.1128/JB.01359-06. Epub 2007 Jan 5.
Abstract
A survey of 30 representative strains of human gram-positive intestinal bacteria indicated that Roseburia species were among the most active in metabolizing linoleic acid (cis-9,cis-12-18:2). Different Roseburia spp. formed either vaccenic acid (trans-11-18:1) or a 10-hydroxy-18:1; these compounds are precursors of the health-promoting conjugated linoleic acid cis-9,trans-11-18:2 in human tissues and the intestine, respectively.
摘要
一项对30种具有代表性的人类革兰氏阳性肠道细菌菌株的调查表明，罗斯氏菌属是代谢亚油酸（顺式-9，顺式-12-18:2）最活跃的菌属之一。不同的罗斯氏菌属菌株分别形成了反式-11-十八碳烯酸（反式-11-18:1）或10-羟基-18:1；这些化合物分别是人体组织和肠道中具有健康促进作用的共轭亚油酸顺式-9，反式-11-18:2的前体。
相似文献
1
Metabolism of linoleic acid by human gut bacteria: different routes for biosynthesis of conjugated linoleic acid.人体肠道细菌对亚油酸的代谢：共轭亚油酸生物合成的不同途径。
J Bacteriol. 2007 Mar;189(6):2566-70. doi: 10.1128/JB.01359-06. Epub 2007 Jan 5.
2
Mechanism of conjugated linoleic acid and vaccenic acid formation in human faecal suspensions and pure cultures of intestinal bacteria.共轭亚油酸和反式vaccenic酸在人粪便悬液及肠道细菌纯培养物中的形成机制
Microbiology (Reading). 2009 Jan;155(Pt 1):285-294. doi: 10.1099/mic.0.022921-0.
3
Yeast cell surface display of linoleic acid isomerase from Propionibacterium acnes and its application for the production of trans-10, cis-12 conjugated linoleic acid.痤疮丙酸杆菌亚油酸异构酶的酵母细胞表面展示及其在反式-10，顺式-12共轭亚油酸生产中的应用。
Biotechnol Appl Biochem. 2015 Jan-Feb;62(1):1-8. doi: 10.1002/bab.1249. Epub 2014 Nov 17.
4
5
Production of conjugated fatty acids by lactic acid bacteria.乳酸菌共轭脂肪酸的产生
J Biosci Bioeng. 2005 Oct;100(4):355-64. doi: 10.1263/jbb.100.355.
6
Biochemistry of PUFA double bond isomerases producing conjugated linoleic acid.产生共轭亚油酸的多不饱和脂肪酸双键异构酶的生物化学
Chembiochem. 2008 Aug 11;9(12):1867-72. doi: 10.1002/cbic.200800141.
7
Use of principal component analysis to investigate the origin of heptadecenoic and conjugated linoleic acids in milk.使用主成分分析研究牛奶中十七碳烯酸和共轭亚油酸的来源。
J Dairy Sci. 2003 Dec;86(12):4047-53. doi: 10.3168/jds.S0022-0302(03)74016-8.
8
Kinetics of microbial hydrogenation of free linoleic acid to conjugated linoleic acids.游离亚油酸微生物氢化生成共轭亚油酸的动力学
J Appl Microbiol. 2008 Dec;105(6):2239-47. doi: 10.1111/j.1365-2672.2008.03937.x. Epub 2008 Nov 1.
9
Production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus Mortierella alpina.通过在产油真菌高山被孢霉中异源表达亚油酸异构酶生产共轭亚油酸
Biotechnol Lett. 2015 Oct;37(10):1983-92. doi: 10.1007/s10529-015-1871-8. Epub 2015 Jun 25.
10
Mining the microbiota of the neonatal gastrointestinal tract for conjugated linoleic acid-producing bifidobacteria.从新生儿胃肠道微生物群中挖掘产共轭亚油酸的双歧杆菌。
Appl Environ Microbiol. 2004 Aug;70(8):4635-41. doi: 10.1128/AEM.70.8.4635-4641.2004.
引用本文的文献
1
A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut.一种源自新生儿的单克隆IgM抗体可选择性调节肠道中的微生物代谢。
Nat Commun. 2025 Sep 29;16(1):8563. doi: 10.1038/s41467-025-63585-x.
2
A review of the relationship between gut microbiota and osteoporosis in high altitude environments.高海拔环境中肠道微生物群与骨质疏松症关系的综述
J Health Popul Nutr. 2025 Jul 7;44(1):241. doi: 10.1186/s41043-025-00994-0.
3
Breed-specific differences of gut microbiota and metabolomic insights into fat deposition and meat quality in Chinese Songliao Black Pig and Large White × Landrace Pig Breeds.中国松辽黑猪和大白×长白猪品种肠道微生物群的品种特异性差异以及对脂肪沉积和肉质的代谢组学见解
BMC Microbiol. 2025 May 28;25(1):334. doi: 10.1186/s12866-025-04051-y.
4
Uncovering the heterogeneity of the gut microbial taxa associated with the contents of different fatty acids in muscle with cecum luminal content and fecal samples from two pig populations.利用来自两个猪群的盲肠腔内容物和粪便样本，揭示与肌肉中不同脂肪酸含量相关的肠道微生物分类群的异质性。
Front Microbiol. 2025 Apr 30;16:1575383. doi: 10.3389/fmicb.2025.1575383. eCollection 2025.
5
Precision Dietary Intervention: Gut Microbiome and Meta-metabolome as Functional Readouts.精准饮食干预：以肠道微生物组和代谢组作为功能读数
Phenomics. 2025 Feb 14;5(1):23-50. doi: 10.1007/s43657-024-00193-7. eCollection 2025 Feb.
6
A Diet Fortified with Anthocyanin-Rich Extract (RED) Reduces Ileal Inflammation in a Senescence-Prone Mice Model of Crohn's-Disease-like Ileitis.富含花青素提取物（RED）强化饮食可减轻克罗恩病样回肠炎易衰老小鼠模型的回肠炎症。
Antioxidants (Basel). 2025 Apr 15;14(4):473. doi: 10.3390/antiox14040473.
7
Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics.肠道微生物群与宿主化学通讯的表型分析：次级胆汁酸作为益生元后体。
Cells. 2025 Apr 15;14(8):595. doi: 10.3390/cells14080595.
8
Neonatal gut microbiota succession in mice mapped over time, site, injury and single immunoglobulin interleukin-1 related receptor genotype.小鼠新生儿肠道微生物群随时间、部位、损伤和单免疫球蛋白白细胞介素-1相关受体基因型的演替情况。
iScience. 2025 Mar 18;28(4):112243. doi: 10.1016/j.isci.2025.112243. eCollection 2025 Apr 18.
9
Exploring the microbiota-gut-brain axis: impact on brain structure and function.探索微生物群-肠道-脑轴：对脑结构和功能的影响。
Front Neuroanat. 2025 Feb 12;19:1504065. doi: 10.3389/fnana.2025.1504065. eCollection 2025.
10
Therapeutic Strategies to Modulate Gut Microbial Health: Approaches for Chronic Metabolic Disorder Management.调节肠道微生物健康的治疗策略：慢性代谢紊乱管理方法
Metabolites. 2025 Feb 13;15(2):127. doi: 10.3390/metabo15020127.
本文引用的文献
1
Clostridium proteoclasticum: A ruminal bacterium that forms stearic acid from linoleic acid.解朊梭菌：一种能将亚油酸转化为硬脂酸的瘤胃细菌。
FEMS Microbiol Lett. 2006 Dec;265(2):195-201. doi: 10.1111/j.1574-6968.2006.00487.x.
2
Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen.多不饱和脂肪酸的代谢及其对瘤胃微生物区系的毒性。
Antonie Van Leeuwenhoek. 2007 May;91(4):303-14. doi: 10.1007/s10482-006-9118-2. Epub 2006 Oct 28.
3
Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces.基于从人类粪便中分离出的菌株，提出新种粪便罗斯氏菌、人罗斯氏菌和食菊糖罗斯氏菌。
Int J Syst Evol Microbiol. 2006 Oct;56(Pt 10):2437-2441. doi: 10.1099/ijs.0.64098-0.
4
5
Molecular diversity, cultivation, and improved detection by fluorescent in situ hybridization of a dominant group of human gut bacteria related to Roseburia spp. or Eubacterium rectale.与罗斯氏菌属或直肠真杆菌相关的人类肠道优势菌群的分子多样性、培养及荧光原位杂交检测的改进
Appl Environ Microbiol. 2006 Sep;72(9):6371-6. doi: 10.1128/AEM.00701-06.
6
Influence of fish oil on ruminal biohydrogenation of C18 unsaturated fatty acids.鱼油对C18不饱和脂肪酸瘤胃生物氢化的影响。
Br J Nutr. 2006 Jun;95(6):1199-211. doi: 10.1079/bjn20061783.
7
Design and validation of 16S rRNA probes to enumerate members of the Clostridium leptum subgroup in human faecal microbiota.用于计数人类粪便微生物群中纤细梭菌亚组成员的16S rRNA探针的设计与验证
Environ Microbiol. 2005 Jul;7(7):933-46. doi: 10.1111/j.1462-2920.2005.00763.x.
8
Diversity of the human intestinal microbial flora.人类肠道微生物群的多样性。
Science. 2005 Jun 10;308(5728):1635-8. doi: 10.1126/science.1110591. Epub 2005 Apr 14.
9
Metabolic and health effects of isomeric fatty acids.异构脂肪酸的代谢及健康影响
Curr Opin Lipidol. 2005 Feb;16(1):27-30. doi: 10.1097/00041433-200502000-00006.
10
Conjugated linoleic acids: are they beneficial or detrimental to health?共轭亚油酸：它们对健康有益还是有害？
Prog Lipid Res. 2004 Nov;43(6):553-87. doi: 10.1016/j.plipres.2004.08.002.
Zotero 插件