Chavarro Jorge E, Rich-Edwards Janet W, Rosner Bernard A, Willett Walter C
Department of Nutrition, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Am J Clin Nutr. 2007 Jan;85(1):231-7. doi: 10.1093/ajcn/85.1.231.
Pharmacologic activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) improves ovulatory function in women with polycystic ovary syndrome, and specific dietary fatty acids can affect PPAR-gamma activity.
The objective of the study was to assess whether the intakes of total fat, cholesterol, and major types of fatty acids affect the risk of ovulatory infertility.
We conducted a prospective cohort study of 18 555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999. Diet was assessed twice during follow-up by using a food-frequency questionnaire.
During follow-up, 438 incidents of ovulatory infertility were reported. In logistic regression analyses, intakes of total fat, cholesterol, and most types of fatty acids were not related to ovulatory infertility. Each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from carbohydrates, was associated with a 73% greater risk of ovulatory infertility after adjustment for known and suspected risk factors for this condition [relative risk (RR) = 1.73; 95% CI: 1.09, 2.73]. Obtaining 2% of energy intake from trans fats rather than from n-6 polyunsaturated fats was associated with a similar increase in the risk of ovulatory infertility (RR = 1.79; 95% CI: 1.11, 2.89). In addition, obtaining 2% of energy from trans fats rather than from monounsaturated fats was associated with a more than doubled risk of ovulatory infertility (RR = 2.31; 95% CI: 1.09, 4.87).
trans Unsaturated fats may increase the risk of ovulatory infertility when consumed instead of carbohydrates or unsaturated fats commonly found in nonhydrogenated vegetable oils.
过氧化物酶体增殖物激活受体γ（PPAR-γ）的药物激活可改善多囊卵巢综合征女性的排卵功能，特定膳食脂肪酸可影响PPAR-γ活性。
本研究旨在评估总脂肪、胆固醇和主要脂肪酸类型的摄入量是否会影响排卵性不孕的风险。
我们对18555名已婚、绝经前且无不孕史的女性进行了一项前瞻性队列研究，这些女性在1991年至1999年间尝试怀孕或已怀孕。在随访期间通过食物频率问卷对饮食进行了两次评估。
随访期间，报告了438例排卵性不孕事件。在逻辑回归分析中，总脂肪、胆固醇和大多数脂肪酸类型的摄入量与排卵性不孕无关。与碳水化合物相比，反式不饱和脂肪提供的能量每增加2%，在对该疾病已知和可疑风险因素进行调整后，排卵性不孕的风险增加73%[相对风险（RR）=1.73；95%置信区间：1.09，2.73]。反式脂肪提供2%的能量摄入而非n-6多不饱和脂肪与排卵性不孕风险的类似增加相关（RR = 1.79；95%置信区间：1.11，2.89）。此外，反式脂肪提供2%的能量摄入而非单不饱和脂肪与排卵性不孕风险增加一倍以上相关（RR = 2.31；95%置信区间：1.09，4.87）。
当食用反式不饱和脂肪而非碳水化合物或非氢化植物油中常见的不饱和脂肪时，可能会增加排卵性不孕的风险。
