Department of Gynecology, First People's Hospital of Chongqing Liang Jiang New Area, No. 199 Renxing Road, Renhe Street, Liangjiang New Area, Chongqing, 401121, China.
Department of Reproductive Medicine, Lanzhou University Second Hospital, Lanzhou, 730030, China.
Lipids Health Dis. 2024 Nov 15;23(1):377. doi: 10.1186/s12944-024-02366-9.
Some research indicates that unsaturated fatty acids (UFAs) in the diet could enhance reproductive outcomes in infertile women. However, other research holds different views, possibly due to differences in the conversion rates of UFAs from various foods and bioavailability in the body. Therefore, this research examined the link between serum UFAs and infertility issues.
This research included reproductive-age women participating in the 2013-2014 American National Health and Nutrition Examination Survey (NHANES). Serum levels of four UFAs, including palmitoleic acid (16:1n-7), vaccenic acid (18:1n-7), oleic acid (18:1n-9), and linoleic acid (18:2n-6) were measured through gas chromatography-mass spectrometry. Infertility data was collected by affirmative responses to targeted questionnaire items. Associations between serum UFA levels and infertility were evaluated utilizing Poisson regression models and smooth curve fitting methods. Sensitivity analysis was also conducted.
This study included 535 women, aged between 18 and 45. Poisson regression analysis, both adjusted and unadjusted for confounders, revealed no associations between palmitoleic acid, vaccenic acid, oleic acid, or linoleic acid and female infertility (all P > 0.05). However, four UFAs all showed non-linear relationships with infertility in smooth curve fitting analysis. Sensitivity analysis confirmed the stability of the findings.
This research established non-linear associations between serum UFAs and infertility in American women. Specifically, maintaining appropriate serum levels of these UFAs may lower infertility risk. These findings offer new insights and practical dietary recommendations for improving female fertility.
一些研究表明，饮食中的不饱和脂肪酸（UFAs）可以提高不孕女性的生殖效果。然而，其他研究则持有不同的观点，这可能是由于不同食物来源的 UFAs 的转化率和体内的生物利用度不同所致。因此，本研究探讨了血清 UFAs 与不孕问题之间的联系。
本研究纳入了参加 2013-2014 年美国国家健康和营养调查（NHANES）的育龄期女性。通过气相色谱-质谱法测量了四种血清 UFAs（包括棕榈油酸（16:1n-7）、反式-11-十八碳烯酸（18:1n-7）、油酸（18:1n-9）和亚油酸（18:2n-6）的水平。通过对针对性问卷项目的肯定回答来收集不孕数据。采用泊松回归模型和光滑曲线拟合方法评估血清 UFA 水平与不孕之间的关联，并进行敏感性分析。
本研究纳入了 535 名年龄在 18 至 45 岁之间的女性。调整和未调整混杂因素的泊松回归分析均显示，棕榈油酸、反式-11-十八碳烯酸、油酸和亚油酸与女性不孕之间均无关联（均 P>0.05）。然而，在光滑曲线拟合分析中，这四种 UFA 均与不孕呈非线性关系。敏感性分析证实了研究结果的稳定性。
本研究在美国女性中确立了血清 UFAs 与不孕之间的非线性关联。具体而言，维持适当的血清 UFAs 水平可能会降低不孕风险。这些发现为改善女性生育能力提供了新的见解和实用的饮食建议。
