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谷胱甘肽和抗坏血酸对大肠杆菌链霉素敏感性的影响。

Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli.

作者信息

Goswami Manish, Mangoli Suhas H, Jawali Narendra

机构信息

Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.

出版信息

Antimicrob Agents Chemother. 2007 Mar;51(3):1119-22. doi: 10.1128/AAC.00779-06. Epub 2007 Jan 8.

DOI:10.1128/AAC.00779-06
PMID:17210778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1803111/
Abstract

We examined the effects of antioxidants and the role of reactive oxygen species (ROS) on the antibacterial action of aminoglycosides in Escherichia coli. We concluded that reduced streptomycin sensitivity in the presence of glutathione and ascorbic acid is not due to the antioxidant-mediated scavenging of ROS.

摘要

我们研究了抗氧化剂的作用以及活性氧（ROS）在氨基糖苷类抗生素对大肠杆菌抗菌作用中的角色。我们得出结论，在谷胱甘肽和抗坏血酸存在的情况下链霉素敏感性降低并非由于抗氧化剂介导的ROS清除作用。

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Antimicrob Agents Chemother. 2006 Mar;50(3):949-54. doi: 10.1128/AAC.50.3.949-954.2006.
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Induction of the heat shock regulon in response to increased mistranslation requires oxidative modification of the malformed proteins.响应错义翻译增加而诱导热休克调节子需要对畸形蛋白质进行氧化修饰。
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