Stripf E A, Kühnemund M, Selivanova O, Mann W J
Universitäts HNO-Klinik, Langenbeckstr. 1, 55101 Mainz.
HNO. 2007 May;55 Suppl 1:E1-6. doi: 10.1007/s00106-006-1486-4.
Obstructive sleep apnea syndrome is a "systemic disease" of the upper airways and the upper digestive tract. The concept of multilevel surgery takes account of the fact that the location of the obstruction frequently cannot be identified precisely.
In this retrospective study over 4 years, data on 25 patients (median age 49.9 years) with moderate to severe OSAS treated with a surgical multilevel therapy were statistically evaluated. The treatment carried out consisted in reduction of the inferior turbinate, if necessary combined with septum plasty, and conventional uvulopalatopharyngoplasty (UPPP), combined with tonsillectomy and radiofrequency therapy of the base of the tongue if appropriate. Pre- and postoperative clinical and polysomnographical checks were performed.
The mean apnea-hypopnea index (AHI) was 39.2+/-19.7/h before surgery. Postoperatively a highly significant reduction of AHI to 16.5+/-9.9/h (p<0.0001) was seen. In 13 out of 25 patients (52%) the disease was cured (AHI<20 and 50% reduction). In 23 patients the AHI improved. In 15 patients AHI was reduced by more than 50%.
Multilevel surgery should be considered as an alternative for patients suffering from OSAS, especially in view of the poor long-term results in patients who receive CPAP therapy or are intolerant to CPAP.
阻塞性睡眠呼吸暂停综合征是上呼吸道和上消化道的一种“全身性疾病”。多级手术的概念考虑到梗阻部位常常无法精确确定这一事实。
在这项为期4年的回顾性研究中,对25例(中位年龄49.9岁)接受多级手术治疗的中重度阻塞性睡眠呼吸暂停低通气综合征(OSAS)患者的数据进行了统计学评估。所实施的治疗包括下鼻甲缩小术(必要时联合鼻中隔成形术)以及传统传统传统悬雍垂腭咽成形术(UPPP),并酌情联合扁桃体切除术和舌根射频治疗。术前和术后均进行了临床及多导睡眠图检查。
术前平均呼吸暂停低通气指数(AHI)为39.2±19.7次/小时。术后AHI显著降低至16.5±9.9次/小时(p<0.0001)。25例患者中有13例(52%)疾病治愈(AHI<20且降低50%)。23例患者的AHI有所改善。15例患者的AHI降低超过50%。
多级手术应被视为阻塞性睡眠呼吸暂停综合征患者的一种替代治疗方法,特别是考虑到接受持续气道正压通气(CPAP)治疗的患者长期效果不佳或不耐受CPAP的情况。