钯催化的一氧化碳通过 C-H 键活化插入 N-磺酰基-2-氨基联苯：一锅法制备生物活性菲啶酮衍生物。
Palladium-catalyzed oxidative insertion of carbon monoxide to N-sulfonyl-2-aminobiaryls through C-H bond activation: access to bioactive phenanthridinone derivatives in one pot.
机构信息
Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30010, Taiwan, ROC.
出版信息
Org Lett. 2013 Apr 5;15(7):1468-71. doi: 10.1021/ol4001922. Epub 2013 Mar 11.
PMID:23477600
Abstract
Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.
摘要
钯催化的 N-磺酰基-2-氨基联苯通过 C-H 键活化和 C-C、C-N 键形成的氧化羰基化反应在无三氟乙酸和更温和的条件下得以发展。该反应能耐受多种底物，并以高达 94%的收率提供具有重要生物学意义的菲啶酮衍生物。
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