Canavan C, Abrams K R, Hawthorne B, Mayberry J F
Digestive Diseases Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, UK.
Aliment Pharmacol Ther. 2007 Jan 1;25(1):59-65. doi: 10.1111/j.1365-2036.2006.03132.x.
To investigate the incidence of death in patients diagnosed with Crohn's disease in Cardiff over 20 years ago.
The Cardiff database of patients with Crohn's disease contains data on all patients diagnosed there since 1934. Patients (394) diagnosed before 1 January 1985 were traced and their mortality status on 31 December 2004 was established.
The overall standardized mortality ratio (SMR) was 1.29 (95% CI 1.12-1.45) and it has not significantly changed since the 1970s. SMR decreases with age, from 16.95 (95% CI 14.99-18.91) for patients aged 10-19 years (although only one death) to 0.92 (95% CI 0.65-1.19) in those over 75 years. Kaplan-Meier analysis of age at death shows that patients diagnosed aged 10-26 years have median age at death of 58 years, those aged 27-52 years of 66 years, those aged 53-58 years of 74 years, and those over 59 years of 79 years.
It shows a significantly raised SMR, not statistically changed since the 1970s and similar to other chronic conditions. Patients diagnosed younger have worse prognosis than those diagnosed later in life and a reduced life expectancy compared with the general population.
调查20多年前在加的夫被诊断为克罗恩病的患者的死亡率。
加的夫克罗恩病患者数据库包含自1934年以来在该地被诊断的所有患者的数据。对1985年1月1日前被诊断的394名患者进行追踪，并确定他们在2004年12月31日的死亡状况。
总体标准化死亡率（SMR）为1.29（95%置信区间1.12 - 1.45），自20世纪70年代以来没有显著变化。SMR随年龄下降，10 - 19岁患者为16.95（95%置信区间14.99 - 18.91）（尽管只有1例死亡），75岁以上患者为0.92（95%置信区间0.65 - 1.
