Hassanyeh F, Marshall E F
Department of Psychiatry, University of Newcastle upon Tyne, United Kingdom.
Acta Psychiatr Scand. 1991 Dec;84(6):561-3. doi: 10.1111/j.1600-0447.1991.tb03195.x.
Thirty-five consecutive attenders at a clinic specializing in anorexia nervosa were studied. All conformed to a DSM-III-R diagnosis for anorexia nervosa. In addition, 3 cases suffered from major depressive disorder and 9 from dysthymia. Blood from all patients was analysed for monoamine oxidase, serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), tryptophan and platelet paroxetine binding. Findings showed that blood 5-HT was higher than normal in all patient groups, and was highest in those having affective disorder with anorexia nervosa. However, of the patients with anorexia nervosa alone, a subgroup having greatest weight loss had blood 5-HT levels significantly below all other groups. Lack of significant changes in other parameters compared with normal subjects points to the possibility of abnormal 5-HT storage or release.
对一家专门治疗神经性厌食症的诊所里连续就诊的35名患者进行了研究。所有患者均符合《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）中神经性厌食症的诊断标准。此外，3例患有重度抑郁症，9例患有心境恶劣障碍。对所有患者的血液进行了单胺氧化酶、血清素（5-羟色胺，5-HT）、5-羟吲哚乙酸（5-HIAA）、高香草酸（HVA）、色氨酸和血小板帕罗西汀结合情况的分析。研究结果表明，所有患者组的血液5-HT水平均高于正常水平，在患有神经性厌食症且伴有情感障碍的患者中最高。然而，在仅患有神经性厌食症的患者中，体重减轻最明显的一个亚组的血液5-HT水平显著低于所有其他组。与正常受试者相比，其他参数没有显著变化，这表明5-HT储存或释放可能存在异常。
