Garibotti Alejandra V, Liao Shiping, Seeman Nadrian C
Department of Chemistry, New York University, New York, New York 10003, USA.
Nano Lett. 2007 Feb;7(2):480-3. doi: 10.1021/nl0628605. Epub 2007 Jan 23.
We have used DNA double crossover (DX) molecules to produce a translation system that generates unique molecular products. The particular species of DX molecule used contains an even number of half-turns between crossover points, so there is a continuous strand on both sides of the molecule. One of these strands acts as the input strand containing the message, and a second strand acts as the product of translation. The crossover strands carry the "code" that connects the two sides of the molecule. This system is more robust, more extendable, and simpler than previous DNA-based translation systems that have been reported. It is designed to be useful in a variety of applications that utilize the concept of translating from one code to another.
我们已使用DNA双交叉（DX）分子来构建一个能产生独特分子产物的翻译系统。所使用的特定种类的DX分子在交叉点之间含有偶数个半圈，因此分子两侧都有一条连续的链。其中一条链作为包含信息的输入链，另一条链作为翻译产物。交叉链携带连接分子两侧的“密码”。该系统比先前报道的基于DNA的翻译系统更稳健、更具扩展性且更简单。它旨在用于各种利用从一种密码转换为另一种密码这一概念的应用中。
