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1

Fine Structure Mapping of the am (Gdh) Locus of Neurospora.神经丝氨酸（Gdh）基因座的精细结构作图。

Genetics. 1983 Oct;105(2):293-307. doi: 10.1093/genetics/105.2.293.

2

Distant upstream regulatory sequences control the level of expression of the am (GDH) locus of Neurospora crassa.远距离上游调控序列控制粗糙脉孢菌am（GDH）基因座的表达水平。

Curr Genet. 1990 Jul;18(1):53-8. doi: 10.1007/BF00321115.

3

Genetic fine structure of the tricarboxylate transport (tct) locus of Salmonella typhimurium.鼠伤寒沙门氏菌三羧酸转运（tct）基因座的遗传精细结构。

Mol Gen Genet. 1983;190(1):20-6. doi: 10.1007/BF00330319.

4

X-ray-induced specific-locus mutations in the ad-3 region of two-component heterokaryons of Neurospora crassa. IV. Irreparable mutants of genotype ad-3A and ad-3B result from multilocus deletion and an unexpectedly high frequency of multiple-locus mutations.粗糙脉孢菌两组分异核体ad-3区域的X射线诱导特异性位点突变。IV. 基因型为ad-3A和ad-3B的不可修复突变体源自多位点缺失和意外高频率的多位点突变。

Mutat Res. 1989 Oct;214(2):297-319. doi: 10.1016/0027-5107(89)90173-5.

5

X-ray-induced specific-locus mutations in the ad-3 region of two-component heterokaryons of Neurospora crassa. V. Irreparable mutants of genotype ad-3A ad-3B, ad-3A ad-3B nic-2, and ad-3B nic-2 result from multilocus deletion and an unexpectedly high frequency of multiple-locus mutations.粗糙脉孢菌双组分异核体ad-3区域的X射线诱导特异性位点突变。V. 基因型为ad-3A ad-3B、ad-3A ad-3B nic-2和ad-3B nic-2的不可修复突变体是由多位点缺失和意外高频率的多位点突变产生的。

Mutat Res. 1990 Mar;229(1):49-67. doi: 10.1016/0027-5107(90)90008-r.

6

X-ray-induced specific locus mutations in the ad-3 region of two-component heterokaryons of Neurospora crassa. III. Genetic fine structure analysis of the ad-3 and immediately adjacent genetic regions by means of complementation tests.X射线诱导粗糙脉孢菌两组分异核体ad-3区域的特定基因座突变。III. 通过互补试验对ad-3及紧邻遗传区域进行遗传精细结构分析。

Mutat Res. 1989 Mar;211(1):89-102. doi: 10.1016/0027-5107(89)90109-7.

7

Nucleotide sequence and nuclear protein binding of the two regulatory sequences upstream of the am (GDH) gene in Neurospora.粗糙脉孢菌中am（GDH）基因上游两个调控序列的核苷酸序列及核蛋白结合情况

Mol Gen Genet. 1990 Apr;221(2):148-54. doi: 10.1007/BF00261714.

8

Cloning of the am (glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe.利用合成DNA探针克隆粗糙脉孢菌的am（谷氨酸脱氢酶）基因。

Gene. 1982 Dec;20(3):387-96. doi: 10.1016/0378-1119(82)90207-4.

9

Use of transformation to make targeted sequence alterations at the am (GDH) locus of Neurospora.利用转化技术在粗糙脉孢菌的am（谷氨酸脱氢酶）基因座进行靶向序列改变。

Mol Gen Genet. 1989 Jun;217(2-3):294-300. doi: 10.1007/BF02464896.

10

New mutational variants of Neurospora NADP-specific glutamate dehydrogenase.粗糙脉孢菌NADP特异性谷氨酸脱氢酶的新突变变体。

Genetics. 1980 Jun;95(2):305-16. doi: 10.1093/genetics/95.2.305.

引用本文的文献

1

Evidence for negative interference: clustering of crossovers close to the am locus in Neurospora crassa among am recombinants.负干扰的证据：粗糙脉孢菌中靠近am基因座的交叉在am重组体间的聚集。

Genetics. 1999 Jul;152(3):965-9. doi: 10.1093/genetics/152.3.965.

2

Gene conversion alone accounts for more than 90% of recombination events at the am locus of Neurospora crassa.仅基因转换就占粗糙脉孢菌am位点重组事件的90%以上。

Genetics. 1996 May;143(1):129-36. doi: 10.1093/genetics/143.1.129.

3

The orientation of gene maps by recombination of flanking markers for the am locus of Neurospora crassa.通过侧翼标记重组对粗糙脉孢菌am基因座进行基因图谱定位。

Curr Genet. 1995 Dec;29(1):27-33. doi: 10.1007/BF00313190.

4

Genetic characterization of the Pto locus of tomato: semi-dominance and cosegregation of resistance to Pseudomonas syringae pathovar tomato and sensitivity to the insecticide Fenthion.番茄Pto基因座的遗传特征：对丁香假单胞菌番茄致病变种的抗性与对杀虫剂倍硫磷的敏感性的半显性及共分离现象

Mol Gen Genet. 1993 May;239(1-2):17-27. doi: 10.1007/BF00281596.

5

Spontaneous mutation during the sexual cycle of Neurospora crassa.粗糙脉孢菌有性生殖周期中的自发突变。

Genetics. 1995 Jan;139(1):137-45. doi: 10.1093/genetics/139.1.137.

6

A selection for myosin heavy chain mutants in the nematode Caenorhabditis elegans.线虫秀丽隐杆线虫中肌球蛋白重链突变体的筛选。

Proc Natl Acad Sci U S A. 1984 Jul;81(14):4470-4. doi: 10.1073/pnas.81.14.4470.

7

Transformation of Neurospora crassa with the cloned am (glutamate dehydrogenase) gene.用克隆的am（谷氨酸脱氢酶）基因转化粗糙脉孢菌。

Mol Cell Biol. 1984 Jan;4(1):117-22. doi: 10.1128/mcb.4.1.117-122.1984.

8

Transformation of Neurospora crassa with recombinant plasmids containing the cloned glutamate dehydrogenase (am) gene: evidence for autonomous replication of the transforming plasmid.用含有克隆的谷氨酸脱氢酶（am）基因的重组质粒转化粗糙脉孢菌：转化质粒自主复制的证据。

Mol Cell Biol. 1984 Oct;4(10):2041-51. doi: 10.1128/mcb.4.10.2041-2051.1984.

9

Relationship of vector insert size to homologous integration during transformation of Neurospora crassa with the cloned am (GDH) gene.用克隆的am（GDH）基因转化粗糙脉孢菌过程中载体插入片段大小与同源整合的关系。

Mol Gen Genet. 1990 Mar;221(1):37-43. doi: 10.1007/BF00280365.

本文引用的文献

1

ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE.论遗传精细结构的拓扑学

Proc Natl Acad Sci U S A. 1961 Mar;47(3):403-15. doi: 10.1073/pnas.47.3.403.

2

ON THE TOPOLOGY OF THE GENETIC FINE STRUCTURE.论遗传精细结构的拓扑学

Proc Natl Acad Sci U S A. 1959 Nov;45(11):1607-20. doi: 10.1073/pnas.45.11.1607.

3

New mutational variants of Neurospora NADP-specific glutamate dehydrogenase.粗糙脉孢菌NADP特异性谷氨酸脱氢酶的新突变变体。

Genetics. 1980 Jun;95(2):305-16. doi: 10.1093/genetics/95.2.305.

4

Frameshift mutations affecting the N-terminal sequence of Neurospora NADP-specific glutamate dehydrogenase.影响粗糙脉孢菌NADP特异性谷氨酸脱氢酶N端序列的移码突变。

J Mol Biol. 1980 Feb 25;137(2):125-35. doi: 10.1016/0022-2836(80)90320-4.

5

Cloning of the am (glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe.利用合成DNA探针克隆粗糙脉孢菌的am（谷氨酸脱氢酶）基因。

Gene. 1982 Dec;20(3):387-96. doi: 10.1016/0378-1119(82)90207-4.

6

A new map of the amination-1 locus of Neurospora crassa, and the effect of the recombination-3 gene.粗糙脉孢菌胺化-1基因座的新图谱以及重组-3基因的作用。

Aust J Biol Sci. 1973 Dec;26(6):1355-70. doi: 10.1071/bi9731355.

7

Amino-acid sequence of NADP-specific glutamate dehydrogenase of neurospora crassa.粗糙脉孢菌NADP特异性谷氨酸脱氢酶的氨基酸序列。

Proc Natl Acad Sci U S A. 1974 Nov;71(11):4361-5. doi: 10.1073/pnas.71.11.4361.

8

Fine-structure mapping of the acetamidase structural gene and its controlling region in Aspergillus nidulans.构巢曲霉中乙酰胺酶结构基因及其控制区域的精细结构图谱

Genetics. 1979 Mar;91(3):381-92. doi: 10.1093/genetics/91.3.381.

9

The molecular basis of an osmotically reparable mutant of Neurospora crassa producing unstable glutamate dehydrogenase.粗糙脉孢菌产生不稳定谷氨酸脱氢酶的渗透可修复突变体的分子基础。

J Mol Biol. 1977 Mar 15;110(4):627-42. doi: 10.1016/s0022-2836(77)80081-8.

10

Mutation induction by difunctional alkylating agents in Neurospora crassa.双功能烷化剂在粗糙脉孢菌中诱导突变

Genetics. 1975 Jul;80(3):475-82. doi: 10.1093/genetics/80.3.475.

神经丝氨酸（Gdh）基因座的精细结构作图。

Fine Structure Mapping of the am (Gdh) Locus of Neurospora.

机构信息

Department of Microbiology, University of Kansas Medical Center, Kansas City, Kansas 66103.

出版信息

Genetics. 1983 Oct;105(2):293-307. doi: 10.1093/genetics/105.2.293.

DOI:10.1093/genetics/105.2.293

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1202158/

Abstract

Utilizing a combination of flanking marker analysis and deletion mapping we have constructed a fine structure map of the am locus which includes 63 point mutants and ten unique deletions. Positions of point mutants can be rapidly assigned to one of 13 segments within the gene on the basis of crosses to nine deletion strains.

摘要

利用侧翼标记分析和缺失作图相结合的方法，我们构建了 am 基因座的精细结构图谱，其中包括 63 个点突变和 10 个独特的缺失。根据与 9 个缺失株系的杂交，可以快速将点突变的位置分配到基因的 13 个片段之一。