Genetics. 1979 Apr;91(4):627-37. doi: 10.1093/genetics/91.4.627.
Colicin-producing plasmid-containing cells of E. coli exhibit frequency-dependent selection when grown in glucose-limited continuous culture with the corresponding plasmid-free strain. The bases of this frequency-dependent effect are shown to be (1) the lower growth rate of the plasmid-containing strain under these conditions, and (2) the production of colicin, which attenuates the growth rate of the plasmid-free strain. These results are discussed in relationship to the maintenance of genetic variation in prokaryotes.
当含有大肠埃希氏菌 colicin 产生质粒的细胞在葡萄糖限制的连续培养中与相应的无质粒菌株一起生长时,会表现出频率依赖性选择。这种频率依赖性效应的基础是:(1) 质粒携带菌株在这些条件下的生长速度较低,和 (2) colicin 的产生,这会降低无质粒菌株的生长速度。这些结果与原核生物遗传变异的维持有关。