Sugni Michela, Mozzi Daniela, Barbaglio Alice, Bonasoro Francesco, Candia Carnevali Maria Daniela
Dipartimento di Biologia, Università degli Studi di Milano, Via Celoria 26, I-20133 Milano, Italy.
Ecotoxicology. 2007 Feb;16(1):95-108. doi: 10.1007/s10646-006-0119-8.
Echinoderms are valuable test species in marine ecotoxicology and offer a wide range of biological processes appropriate for this approach. In spite of this potential, available data in literature are still rather limited, particularly with regard to the possible effects of endocrine disrupter compounds (EDCs). This review presents echinoderms as useful models for ecotoxicological tests and gives a brief overview of the most significant results obtained in recent years, particularly in the context of the COMPRENDO EU project. In this research project two different aspects of echinoderm physiology, plausibly regulated by humoral mechanisms, were investigated: reproductive biology and regenerative development. Selected EDCs suspected for their androgenic or antiandrogenic action were tested at low concentrations. The results obtained so far showed that different parameters such as regenerative growth, histological pattern, egg diameter and gonad maturation were affected by the exposure to the selected compounds. These results substantiate that reproductive and regenerative phenomena of echinoderms can be considered valuable alternative models for studies on EDCs and confirm that these compounds interfere with fundamental physiological processes, including growth, development and reproductive competence.
棘皮动物是海洋生态毒理学中有价值的试验物种，具有适用于该方法的广泛生物过程。尽管有这种潜力，但文献中的现有数据仍然相当有限，特别是关于内分泌干扰化合物（EDCs）的可能影响。本综述将棘皮动物作为生态毒理学试验的有用模型，并简要概述了近年来获得的最重要结果，特别是在欧盟COMPRENDO项目的背景下。在这个研究项目中，研究了棘皮动物生理学中可能受体液机制调节的两个不同方面：生殖生物学和再生发育。对怀疑具有雄激素或抗雄激素作用的选定EDCs进行了低浓度测试。迄今为止获得的结果表明，再生生长、组织学模式、卵直径和性腺成熟等不同参数受到所选化合物暴露的影响。这些结果证实，棘皮动物的生殖和再生现象可被视为研究EDCs的有价值替代模型，并证实这些化合物会干扰包括生长、发育和生殖能力在内的基本生理过程。
