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Development of a semiquantitative degenerate real-time pcr-based assay for estimation of numbers of butyryl-coenzyme A (CoA) CoA transferase genes in complex bacterial samples.开发一种基于半定量简并实时PCR的检测方法，用于估计复杂细菌样本中丁酰辅酶A（CoA）CoA转移酶基因的数量。
Appl Environ Microbiol. 2007 Mar;73(6):2009-12. doi: 10.1128/AEM.02561-06. Epub 2007 Jan 26.
2
Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene.通过分析丁酰基辅酶 A：乙酸辅酶 A 转移酶基因揭示人类结肠丁酸产生菌的多样性。
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Organization of butyrate synthetic genes in human colonic bacteria: phylogenetic conservation and horizontal gene transfer.人类结肠细菌中丁酸盐合成基因的组织：系统发育保守性与水平基因转移
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4
Quantification of butyryl CoA:acetate CoA-transferase genes reveals different butyrate production capacity in individuals according to diet and age.定量分析丁酰辅酶 A:乙酰辅酶 A 转移酶基因可揭示不同饮食和年龄个体的丁酸产生能力。
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Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine.细菌丁酰辅酶A：乙酸盐转移酶的功能与系统发育及其在猪近端结肠中的多样性
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Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer's disease.可培养的产丁酸菌与老年日本阿尔茨海默病患者。
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A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria.一类参与产丁酸的人体结肠细菌中短链脂肪酸代谢的新型辅酶A转移酶。
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Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrate-producing bacteria in the human large intestine.部分水解瓜尔胶可刺激人体大肠中的双歧杆菌和产生丁酸的细菌。
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6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.来自专性厌氧菌的6-氧代环己-1-烯-1-羰基辅酶A水解酶：特性鉴定及其基因作为芳香族化合物降解厌氧菌功能标记的鉴定
Environ Microbiol. 2008 Jun;10(6):1547-56. doi: 10.1111/j.1462-2920.2008.01570.x. Epub 2008 Feb 28.

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Intestinal acetate and butyrate availability is associated with glucose metabolism in healthy individuals.在健康个体中，肠道中乙酸盐和丁酸盐的可利用性与葡萄糖代谢相关。
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本文引用的文献

1
Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces.肥胖受试者减少碳水化合物的饮食摄入量会导致粪便中丁酸盐和产丁酸盐细菌的浓度降低。
Appl Environ Microbiol. 2007 Feb;73(4):1073-8. doi: 10.1128/AEM.02340-06. Epub 2006 Dec 22.
2
Molecular diversity, cultivation, and improved detection by fluorescent in situ hybridization of a dominant group of human gut bacteria related to Roseburia spp. or Eubacterium rectale.与罗斯氏菌属或直肠真杆菌相关的人类肠道优势菌群的分子多样性、培养及荧光原位杂交检测的改进
Appl Environ Microbiol. 2006 Sep;72(9):6371-6. doi: 10.1128/AEM.00701-06.
3
Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut.青春双歧杆菌与人体肠道中产生丁酸的厌氧菌之间代谢互养的两条途径。
Appl Environ Microbiol. 2006 May;72(5):3593-9. doi: 10.1128/AEM.72.5.3593-3599.2006.
4
A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria.一类参与产丁酸的人体结肠细菌中短链脂肪酸代谢的新型辅酶A转移酶。
Microbiology (Reading). 2006 Jan;152(Pt 1):179-185. doi: 10.1099/mic.0.28412-0.
5
Colonic microbiota signatures across five northern European countries.北欧五个国家的结肠微生物群特征
Appl Environ Microbiol. 2005 Jul;71(7):4153-5. doi: 10.1128/AEM.71.7.4153-4155.2005.
6
pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon.pH值和肽供应可从根本上改变人类结肠微生物群落中的细菌种群和短链脂肪酸比例。
Appl Environ Microbiol. 2005 Jul;71(7):3692-700. doi: 10.1128/AEM.71.7.3692-3700.2005.
7
Divergence and redundancy of 16S rRNA sequences in genomes with multiple rrn operons.具有多个rrn操纵子的基因组中16S rRNA序列的差异与冗余
J Bacteriol. 2004 May;186(9):2629-35. doi: 10.1128/JB.186.9.2629-2635.2004.
8
Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon.丁酸盐激酶途径在人结肠中产生丁酸盐的细菌之间的分布受限。
J Bacteriol. 2004 Apr;186(7):2099-106. doi: 10.1128/JB.186.7.2099-2106.2004.
9
The microbiology of butyrate formation in the human colon.人类结肠中丁酸盐形成的微生物学
FEMS Microbiol Lett. 2002 Dec 17;217(2):133-9. doi: 10.1111/j.1574-6968.2002.tb11467.x.
10
Influence of resistant starch on the SCFA production and cell counts of butyrate-producing Eubacterium spp. in the human intestine.抗性淀粉对人肠道中丁酸产生菌属短链脂肪酸产量及细胞计数的影响。
J Appl Microbiol. 2002;93(1):157-62. doi: 10.1046/j.1365-2672.2002.01679.x.

开发一种基于半定量简并实时PCR的检测方法，用于估计复杂细菌样本中丁酰辅酶A（CoA）CoA转移酶基因的数量。

Development of a semiquantitative degenerate real-time pcr-based assay for estimation of numbers of butyryl-coenzyme A (CoA) CoA transferase genes in complex bacterial samples.

作者信息

Louis Petra, Flint Harry J

机构信息

Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom.

出版信息

Appl Environ Microbiol. 2007 Mar;73(6):2009-12. doi: 10.1128/AEM.02561-06. Epub 2007 Jan 26.

DOI:10.1128/AEM.02561-06
PMID:17259367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1828812/
Abstract

We describe a new degenerate real-time PCR approach to simultaneously quantify phylogenetically different butyrate-producing bacteria based on the detection of butyryl-coenzyme A (CoA) CoA transferase genes. This pathway is present in numerically important groups of butyrate producers within the human colon, and thus this assay estimates the butyrate-producing ability of the microbiota.

摘要

我们描述了一种新的简并实时聚合酶链反应方法，该方法基于丁酰辅酶A（CoA）CoA转移酶基因的检测，同时对系统发育上不同的产丁酸细菌进行定量。此途径存在于人类结肠中数量众多的产丁酸菌群体中，因此该检测方法可评估微生物群的产丁酸能力。