Müller Kurt, Valentine-Thon Elizabeth
Practice for Dermatology and Environmental Medicine, Isny, Germany.
Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:31-5.
This study was carried out to investigate the potential of titanium to induce hypersensitivity in patients chronically exposed to titanium-based dental or endoprosthetic implants.
Fifty-six patients who had developed clinical symptoms after receiving titanium-based implants were tested in the optimized lymphocyte transformation test MELISA against 10 metals including titanium. Out of 56 patients, 54 were patch-tested with titanium as well as with other metals. The implants were removed in 54 patients (2 declined explantation), and 15 patients were retested in MELISA.
Of the 56 patients tested in MELISA, 21 (37.5%) were positive, 16 (28.6%) ambiguous, and 19 (33.9%) negative to titanium. In the latter group, 11 (57.9%) showed lymphocyte reactivity to other metals, including nickel. All 54 patch-tested patients were negative to titanium. Following removal of the implants, all 54 patients showed remarkable clinical improvement. In the 15 retested patients, this clinical improvement correlated with normalization in MELISA reactivity.
These data clearly demonstrate that titanium can induce clinically-relevant hypersensitivity in a subgroup of patients chronically exposed via dental or endoprosthetic implants.
本研究旨在调查钛对长期接触钛基牙科或体内植入物的患者诱发超敏反应的可能性。
对56例在接受钛基植入物后出现临床症状的患者进行优化的淋巴细胞转化试验MELISA，检测其对包括钛在内的10种金属的反应。56例患者中，54例接受了钛及其他金属的斑贴试验。54例患者（2例拒绝取出植入物）取出了植入物，15例患者再次进行MELISA检测。
在接受MELISA检测的56例患者中，21例（37.5%）对钛呈阳性反应，16例（28.6%）结果不明确，19例（33.9%）对钛呈阴性反应。在后者中，11例（57.9%）对包括镍在内的其他金属表现出淋巴细胞反应性。所有54例接受斑贴试验的患者对钛均呈阴性反应。取出植入物后，所有54例患者的临床症状均有显著改善。在15例再次检测的患者中，这种临床改善与MELISA反应性恢复正常相关。
这些数据清楚地表明，钛可在通过牙科或体内植入物长期接触的患者亚组中诱发具有临床相关性的超敏反应。
