Konold Timm, Davis Andrew, Bone Gemma, Bracegirdle John, Everitt Sharon, Chaplin Melanie, Saunders Ginny C, Cawthraw Saira, Simmons Marion M
Neuropathology, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK.
BMC Vet Res. 2007 Feb 13;3:2. doi: 10.1186/1746-6148-3-2.
Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features. Most cases are detected in apparently healthy sheep and information on the clinical presentation is limited.
This report describes the clinical findings in two sheep notified as scrapie suspects and confirmed as atypical scrapie cases by immunohistochemistry and Western immunoblotting. Although both sheep displayed signs suggestive of a cerebellar dysfunction there was considerable variation in the individual clinical signs, which were similar to classical scrapie.
Any sheep presenting with neurological gait deficits should be assessed more closely for other behavioural, neurological and physical signs associated with scrapie and their presence should lead to the suspicion of scrapie.
非典型羊瘙痒病是一种最近才被认识到的绵羊传染性海绵状脑病，在神经病理学和生化特征上与经典羊瘙痒病不同。大多数病例在看似健康的绵羊中被检测到，关于临床表现的信息有限。
本报告描述了两只被通报为羊瘙痒病疑似病例并通过免疫组织化学和蛋白质免疫印迹法确认为非典型羊瘙痒病病例的绵羊的临床发现。尽管两只绵羊都表现出提示小脑功能障碍的体征，但个体临床体征存在相当大的差异，这与经典羊瘙痒病相似。
任何出现神经步态缺陷的绵羊都应更密切地评估是否存在与羊瘙痒病相关的其他行为、神经和身体体征，这些体征的出现应引起对羊瘙痒病的怀疑。
