澳大利亚的非典型羊瘙痒症。
Atypical scrapie in Australia.
作者信息
Cook R W, Bingham J, Besier A S, Bayley C L, Hawes M, Shearer P L, Yamada M, Bergfeld J, Williams D T, Middleton D J
机构信息
Regional Veterinary Laboratory, NSW Department of Primary Industries, Wollongbar, New South Wales 2480, Australia.
CSIRO, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
出版信息
Aust Vet J. 2016 Dec;94(12):452-455. doi: 10.1111/avj.12529. Epub 2016 Nov 3.
BACKGROUND
Since its initial detection in Norway in 1998, atypical scrapie ('atypical/Nor98 scrapie') has been reported in sheep in the majority of European countries (including in regions free of classical scrapie) and in the Falkland Islands, the USA, Canada, New Zealand and Australia.
CASE SERIES
The diagnosis in Australia of atypical scrapie in four Merino and one Merino-cross sheep showing clinical signs of neurological disease was based on the detection of grey matter neuropil vacuolation (spongiform change) in the brain (particularly in the molecular layer of the cerebellar cortex) and associated abnormal prion protein (PrP ) deposition in both grey and white matter. Changes were minimal in the caudal brainstem, the predilection site for lesions of classical scrapie.
CONCLUSION
The distinctive lesion profile of atypical scrapie in these five sheep highlights the diagnostic importance of routine histological evaluation of the cerebellum for evidence of neuropil vacuolation and associated PrP deposition in adult sheep with suspected neurological disease.
背景
自1998年在挪威首次检测到非典型羊瘙痒病（“非典型/挪威98型羊瘙痒病”）以来，在大多数欧洲国家（包括无经典羊瘙痒病的地区）以及福克兰群岛、美国、加拿大、新西兰和澳大利亚的绵羊中均有报告。
病例系列
在澳大利亚，对四只美利奴羊和一只美利奴杂交羊进行了非典型羊瘙痒病的诊断，这些羊表现出神经疾病的临床症状，诊断依据是在大脑中检测到灰质神经毡空泡化（海绵状变化）（特别是在小脑皮质分子层）以及在灰质和白质中均存在相关的异常朊病毒蛋白（PrP）沉积。在经典羊瘙痒病病变的好发部位——延髓尾端，变化极小。
结论
这五只绵羊中非典型羊瘙痒病独特的病变特征突出了对疑似神经疾病的成年绵羊小脑进行常规组织学评估以寻找神经毡空泡化证据和相关PrP沉积的诊断重要性。
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