Bisceglia M, Bosman C, Quirke P
Department of Anatomical Pathology, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
Cancer. 1992 Feb 1;69(3):793-8. doi: 10.1002/1097-0142(19920201)69:3<793::aid-cncr2820690330>3.0.co;2-a.
One hundred forty-three biopsies of Kaposi's sarcoma (KS) from 96 patients were assessed histopathologically, and mitoses were counted. Ninety-seven samples from 66 patients were analyzed by flow cytometry. Six of 97 (5.8%) KS lesions were DNA aneuploid with a clustering around a DNA index of 1.5 (range, 1.4 to 1.6). The median percentage of S-phase plus G2-phase cells (%S + G2) was 16.7%. Increasing mitotic counts and %S + G2 were seen with progression of the phase and pattern of disease. Nodular KS and spindle cell predominant KS had the highest mitotic counts and %S + G2, with nodular KS larger than 4 mm having a higher mitotic count than those smaller than 4 mm. These findings suggest a low level of DNA aneuploidy in KS and important changes in the level of cell proliferation with the phase and pattern of the disease. However, flow cytometry does not solve the dilemma of whether KS is a hyperplastic or neoplastic process.
对96例患者的143份卡波西肉瘤（KS）活检标本进行了组织病理学评估，并对有丝分裂进行了计数。对66例患者的97份样本进行了流式细胞术分析。97个KS病变中有6个（5.8%）为DNA非整倍体，其DNA指数聚集在1.5左右（范围为1.4至1.6）。S期加G2期细胞的中位数百分比（%S + G2）为16.7%。随着疾病阶段和模式的进展，有丝分裂计数和%S + G2增加。结节性KS和梭形细胞为主的KS有丝分裂计数和%S + G2最高，直径大于4 mm的结节性KS比小于4 mm的有更高的有丝分裂计数。这些发现表明KS中DNA非整倍体水平较低，且细胞增殖水平随疾病阶段和模式发生重要变化。然而，流式细胞术并不能解决KS是增生性还是肿瘤性过程的难题。
