[与干扰素-α和利巴韦林治疗慢性丙型肝炎感染相关的小柳原田病]
[Vogt-Koyanagi-Harada disease associated with interferon-alpha and ribavirin therapy for chronic hepatitis C infection].
作者信息
Chebil A, Kort F, Bouraoui R, Youssef N Ben, El Matri L
机构信息
Service B, Institut Hédi Rais d'ophtalmologie, Tunis, Tunisie.
出版信息
J Fr Ophtalmol. 2010 Mar;33(3):185-8. doi: 10.1016/j.jfo.2010.01.009. Epub 2010 Feb 20.
The complex immunological effects of interferon and ribavirin therapy in hepatitis C virus may also exacerbate or trigger the development of autoimmunity. A rare case of Vogt-Koyanagi-Harada disease associated with ribavirin and interferon-alpha treatment for chronic hepatitis C infection is presented. The potential role of interferon and/or ribavirin therapy is discussed. Physicians should be aware of the association between interferon-alpha 2a and ribavirin use for hepatitis C infection and the development of Harada disease. This severe ophthalmological complication requires close follow-up of hepatitis C virus-infected patients on interferon-alpha treatment.
干扰素和利巴韦林治疗丙型肝炎病毒时的复杂免疫效应也可能会加重或引发自身免疫性疾病的发展。本文报告了1例与利巴韦林和α干扰素治疗慢性丙型肝炎感染相关的Vogt-小柳原田病罕见病例。文中讨论了干扰素和/或利巴韦林治疗的潜在作用。医生应了解使用α干扰素2a和利巴韦林治疗丙型肝炎感染与原田病发展之间的关联。这种严重的眼科并发症需要对接受α干扰素治疗的丙型肝炎病毒感染患者进行密切随访。
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