Safkan-Seppälä B, Ainamo J
Department of Periodontology, University of Helsinki, Finland.
J Clin Periodontol. 1992 Jan;19(1):24-9. doi: 10.1111/j.1600-051x.1992.tb01144.x.
In the present investigation, the frequency and severity of periodontal disease was assessed in a group of 71 patients with a mean duration of 16.5 years of insulin-dependent diabetes mellitus (IDD). The diabetics, aged 17-63 years, were under treatment at the diabetic outpatient clinic of the III Department of Medicine, University Central Hospital of Helsinki and at two clinics of the Helsinki Health Centre. Based upon their long-term medical records, 44 individuals were assessed to have a poorly controlled insulin-dependent diabetes mellitus (PIDD). At baseline of the present study, the PIDD group had a mean blood glucose level of 11.8 mmol/l and a mean glycosylated hemoglobin (HBA1) level of 10.7%. 27 subjects were classified as having a controlled insulin-dependent diabetes mellitus (CIDD). For each individual, site-specific recordings were made for the plaque index, gingival index, pocket depth, loss of attachment, bleeding after probing, gingival recession and radiographic loss of alveolar bone. Under similar plaque conditions, adult subjects with a long-term PIDD were found to have lost more approximal attachment and bone than subjects with a CIDD (P = 0.046, P = 0.019). These differences were not equally obvious when the subjects were classified according to the history of medical complications, such as retinopathies, neuropathies and nephropathies.
在本研究中，对一组71例胰岛素依赖型糖尿病（IDD）平均病程为16.5年的患者的牙周疾病频率和严重程度进行了评估。这些年龄在17至63岁之间的糖尿病患者正在赫尔辛基大学中心医院医学第三科的糖尿病门诊以及赫尔辛基健康中心的两家诊所接受治疗。根据他们的长期病历，44人被评估为胰岛素依赖型糖尿病控制不佳（PIDD）。在本研究的基线时，PIDD组的平均血糖水平为11.8 mmol/l，平均糖化血红蛋白（HBA1）水平为10.7%。27名受试者被归类为胰岛素依赖型糖尿病得到控制（CIDD）。对每个个体进行了菌斑指数、牙龈指数、牙周袋深度、附着丧失、探诊后出血、牙龈退缩和牙槽骨影像学丧失的部位特异性记录。在相似的菌斑条件下，发现长期患有PIDD的成年受试者比患有CIDD的受试者丧失了更多的邻面附着和骨组织（P = 0.046，P = 0.019）。当根据视网膜病变、神经病变和肾病等医疗并发症史对受试者进行分类时，这些差异并不同样明显。
