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评估唾液和血清碱性磷酸酶水平作为2型糖尿病伴牙周健康与疾病的诊断标志物：一项临床生化研究。

Estimation of salivary and serum alkaline phosphatase level as a diagnostic marker in type-2 diabetes mellitus with periodontal health and disease: A clinico-biochemical study.

作者信息

De Amit, Puttannavar Rekha, Rahman Faizia, Adak Anwesha, Sahoo Rahul, Prakash B S Ravi

机构信息

Department of Periodontics, Haldia Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Department of Oral Medicine and Radiology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

出版信息

J Oral Maxillofac Pathol. 2018 Sep-Dec;22(3):445. doi: 10.4103/jomfp.JOMFP_212_18.

DOI:10.4103/jomfp.JOMFP_212_18
PMID:30651701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6306589/
Abstract

INTRODUCTION

Chronic periodontitis is a multifactorial disease resulting in the inflammation and destruction of the supporting structures around the teeth, leading to tooth mobility and subsequent loss of tooth. Metabolic disorders, such as diabetes mellitus, play a crucial role in the progression of periodontal inflammatory conditions. Alkaline phosphatase (ALP) enzyme plays a key role in gingival inflammation and bone resorption. Hence, the aim of the present study is to compare the serum and salivary alkaline phosphatase levels in chronic periodontitis patients with or without type-2 diabetes mellitus.

MATERIALS AND METHODS

A total of 45 individuals were included in the study and divided into three groups: Group I (healthy individual), Group II (Chronic periodontitis without diabetes mellitus type-2) and Group III (Chronic periodontitis with type-2 diabetes mellitus) on the basis of clinical, radiographic and blood sugar examination. The serum and unstimulated saliva were collected from all patients in aseptic condition and samples were analyzed for alkaline phosphatase level using AVANTOR™ Benesphera ALP Kit by fully automated analyzer.

RESULTS

The result showed that the concentration of serum and salivary alkaline phosphatase increases significantly in patients with chronic periodontitis with type-2 diabetes mellitus than chronic periodontitis without diabetes mellitus and healthy patients.

CONCLUSION

We can conclude that alkaline phosphatase can be used as a key inflammatory diagnostic biomarker in periodontal diseases.

摘要

引言

慢性牙周炎是一种多因素疾病，会导致牙齿周围支持结构的炎症和破坏，进而引起牙齿松动并最终导致牙齿脱落。代谢紊乱，如糖尿病，在牙周炎症状态的进展中起着关键作用。碱性磷酸酶（ALP）在牙龈炎症和骨吸收中起关键作用。因此，本研究的目的是比较患有或未患有2型糖尿病的慢性牙周炎患者的血清和唾液碱性磷酸酶水平。

材料与方法

本研究共纳入45名个体，并根据临床、影像学和血糖检查分为三组：第一组（健康个体）、第二组（无2型糖尿病的慢性牙周炎患者）和第三组（有2型糖尿病的慢性牙周炎患者）。在无菌条件下从所有患者采集血清和非刺激性唾液，并使用全自动分析仪通过AVANTOR™ Benesphera ALP试剂盒分析样本的碱性磷酸酶水平。

结果

结果显示，与无糖尿病的慢性牙周炎患者和健康患者相比，患有2型糖尿病的慢性牙周炎患者血清和唾液碱性磷酸酶的浓度显著升高。

结论

我们可以得出结论，碱性磷酸酶可作为牙周疾病关键的炎症诊断生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/0074550fc6a8/JOMFP-22-445-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/f8d237456ee4/JOMFP-22-445-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/7c4e11c948e9/JOMFP-22-445-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/50322b0ec9d9/JOMFP-22-445-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/bb45e98645a0/JOMFP-22-445-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/0074550fc6a8/JOMFP-22-445-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/f8d237456ee4/JOMFP-22-445-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/6a28fddca7f1/JOMFP-22-445-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/7c4e11c948e9/JOMFP-22-445-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/50322b0ec9d9/JOMFP-22-445-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/bb45e98645a0/JOMFP-22-445-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a19/6306589/0074550fc6a8/JOMFP-22-445-g014.jpg

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