Pettifor Audrey E, MacPhail Catherine, Bertozzi Stefano, Rees Helen V
Department of Epidemiology, CB #7435, McGavran-Greenberg Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA.
Sex Transm Infect. 2007 Aug;83 Suppl 1:i70-74. doi: 10.1136/sti.2006.023689. Epub 2007 Feb 27.
Although 50% of all new global HIV infections occur among young people, our knowledge to date of the impact of adolescent HIV prevention interventions in developing country settings is limited. During 1999, a national HIV prevention programme for youth, called loveLife, was launched in South Africa. This paper describes the challenges faced in trying to evaluate such a national programme and the types of evidence that could be used to better understand the effect of programmes of national scale. A range of methods were planned to evaluate the programme, including national household surveys and programme monitoring data. Given the urgent need to scale-up programmes in an effort to reduce new HIV infections, a range of evidence should be assessed to measure the effect of large-scale, complex behavioural interventions as an alternative to randomised controlled trials.
尽管全球新增的艾滋病病毒感染病例中有50%发生在年轻人当中，但迄今为止，我们对发展中国家青少年艾滋病预防干预措施影响的了解仍然有限。1999年，南非启动了一项名为“热爱生命”的全国青少年艾滋病预防计划。本文描述了在试图评估这样一项全国性计划时所面临的挑战，以及可用于更好地理解全国规模计划效果的证据类型。计划采用一系列方法来评估该计划，包括全国家庭调查和计划监测数据。鉴于迫切需要扩大计划规模以减少新的艾滋病病毒感染病例，应评估一系列证据，以衡量大规模、复杂行为干预措施的效果，作为随机对照试验的替代方法。
