Hooper S M, Newcombe R G, Faller R, Eversole S, Addy M, West N X
Division of Restorative Dentistry, Bristol Dental School, Lower Maudlin Street, Bristol BS1 2LY, UK.
J Dent. 2007 Jun;35(6):476-81. doi: 10.1016/j.jdent.2007.01.003. Epub 2007 Feb 27.
There has been a monumental increase in the consumption of soft drinks, fruit juices and sport drinks in the UK, the US, and many other countries. Previous investigations have demonstrated the erosive nature of these acidic soft drinks. The aim of this investigation was to determine the protective effects of an experimental fluoride-based toothpaste, containing sodium hexametaphosphate, against an erosive challenge on tooth enamel.
The erosion of enamel by orange juice compared the experimental toothpaste with a benchmark sodium fluoride paste and negative control, water, in a 15-day in situ model; and the same in an in vitro enamel erosion model. Flat, polished human enamel samples with a surface profile of +/-0.1mum, were exposed to the three regimens in the single blind, crossover clinical study mimicked in vitro. Depths of the resulting eroded areas were measured using a profilometer.
There was significantly more erosive damage on the specimens exposed to the benchmark paste and water compared to the test paste in both the in situ and in vitro studies.
The data provide further support for tooth brushing before meals. Results of this study further suggest the sodium hexametaphosphate containing paste could be used to provide significant erosion protection in susceptible individuals over that provided by conventional fluoride products.
在英国、美国和许多其他国家,软饮料、果汁和运动饮料的消费量大幅增加。先前的调查已证明这些酸性软饮料具有腐蚀性。本研究的目的是确定一种含六偏磷酸钠的实验性含氟牙膏对牙釉质侵蚀挑战的保护作用。
在一个15天的原位模型中,将橙汁对牙釉质的侵蚀情况,在单盲、交叉临床研究中,将实验牙膏与基准氟化钠牙膏和阴性对照水进行比较;在体外牙釉质侵蚀模型中也进行同样的比较。表面轮廓为+/-0.1微米的扁平、抛光的人牙釉质样本,在模拟体外的实验中接受这三种处理方案。使用轮廓仪测量所得侵蚀区域的深度。
在原位和体外研究中,与测试牙膏相比,暴露于基准牙膏和水的样本的侵蚀损伤明显更多。
这些数据为饭前刷牙提供了进一步的支持。本研究结果进一步表明,与传统含氟产品相比,含六偏磷酸钠的牙膏可用于为易感个体提供显著的防侵蚀保护。