Hughes J A, West N X, Addy M
Department of Oral and Dental Science, Bristol Dental Hospital, Bristol, UK.
J Oral Rehabil. 2004 Apr;31(4):357-63. doi: 10.1046/j.1365-2842.2003.01240.x.
Fluoride is known to reduce enamel solubility during the caries process. The aim of this investigation was to determine whether fluoride preparations affect erosion attributed to citric acid and citric acid-based soft drinks. Flat enamel specimens embedded in epoxy resin were prepared from caries free, human third molar teeth extracted from patients aged 18-35 years. Specimens were polished to have a profile within a tolerance of +/-0.3 microm measured on a profilometer. Specimens were taped to leave a 2 mm window of exposed enamel. Groups of specimens were exposed to citric acid and soft drinks with and without the addition of sodium fluoride or exposed to the same solutions after pre-treatment with fluoride products. Enamel loss was measured by profilometer after 10, 20 and 30 min of acid exposure. The different acidic solutions varied significantly in the amount of erosion produced both with and without the addition of fluoride. In addition, the different fluoride products differed significantly in the protective effect afforded. Both fluoride application methods reduced in mean terms, enamel erosion at all time points and by all acidic solutions. The majority of differences were <25% and as the study was powered to show differences as significant at or above this level few reached statistical significance. Fluoride applied to enamel either in acidic solutions or as a pre-treatment, reduces enamel erosion; however, the actual clinical benefit appears low. More studies are required, including investigations in situ.
已知氟化物在龋齿形成过程中可降低牙釉质的溶解度。本研究的目的是确定氟化物制剂是否会影响由柠檬酸和柠檬酸基软饮料引起的牙釉质侵蚀。从18 - 35岁患者拔除的无龋人类第三磨牙制备嵌入环氧树脂的扁平牙釉质标本。标本经抛光处理，使其轮廓在轮廓仪上测量的公差为+/-0.3微米范围内。将标本用胶带粘贴，留出2毫米的暴露牙釉质窗口。将标本分组，分别暴露于添加或未添加氟化钠的柠檬酸和软饮料中，或在经氟化物产品预处理后暴露于相同溶液中。在酸暴露10、20和30分钟后，用轮廓仪测量牙釉质损失。无论添加氟化物与否，不同的酸性溶液产生的侵蚀量差异显著。此外，不同的氟化物产品所提供的保护作用也有显著差异。两种氟化物应用方法在所有时间点和所有酸性溶液中，均平均减少了牙釉质侵蚀。大多数差异<25%，并且由于该研究旨在显示在此水平或以上的差异具有显著性，因此很少有差异达到统计学显著性。无论是在酸性溶液中还是作为预处理应用于牙釉质的氟化物，均可减少牙釉质侵蚀；然而，实际的临床益处似乎较低。需要进行更多的研究，包括原位研究。
