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记忆再巩固的分子机制。

Molecular mechanisms of memory reconsolidation.

作者信息

Tronson Natalie C, Taylor Jane R

机构信息

Department of Psychiatry, Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06508, USA.

出版信息

Nat Rev Neurosci. 2007 Apr;8(4):262-75. doi: 10.1038/nrn2090.

Abstract

Memory reconsolidation has been argued to be a distinct process that serves to maintain, strengthen or modify memories. Specifically, the retrieval of a previously consolidated memory has been hypothesized to induce an additional activity-dependent labile period during which the memory can be modified. Understanding the molecular mechanisms of reconsolidation could provide crucial insights into the dynamic aspects of normal mnemonic function and psychiatric disorders that are characterized by exceptionally strong and salient emotional memories.

摘要

记忆再巩固被认为是一个独特的过程,用于维持、强化或修改记忆。具体而言,先前巩固的记忆的提取被假设会引发一个额外的依赖活动的不稳定期,在此期间记忆可以被修改。了解再巩固的分子机制可以为正常记忆功能的动态方面以及以异常强烈和突出的情感记忆为特征的精神疾病提供关键见解。

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