Liersch R, Soicke H, Stehr C, Tüllner H U
Dr. Madaus GmbH, Ostmerheimer Str. 198, D-5000 Köln, Federal Republic of Germany.
Planta Med. 1986 Oct(5):387-90. doi: 10.1055/s-2007-969193.
In order to investigate the possibility of isolating greater amounts of the antimalarial compound artemisinin (quinghaosu), plants of ARTEMISIA ANNUA were cultivated and analysed at different stages of development. We found the highest content just before flowering. It was also possible to correlate development of the plants with the maximum content of artemisinin. ARTEMISIA ANNUA plants cultivated from various other sources were also examine for artemisinin content. According to our results, none of these plants contained sufficient amounts of artemisinin to justify an isolation on a technical scale. Furthermore other Artemisia species were tested. We found artemisinin in only one other species. To possibly increase the amount of artemisinin during the growth period of the plant, we tested two hormone-type growth regulators on A. ANNUA strain 811. The results showed that one of them, chlormequat, was able to increase the artemisinin content by 30% over untreated plants. We also found some slight effects of the growth regulators on morphological criteria of glandular trichomes.
为了研究分离出更多抗疟化合物青蒿素（青蒿素）的可能性，对不同发育阶段的黄花蒿植株进行了栽培和分析。我们发现在开花前青蒿素含量最高。还能够将植株的发育与青蒿素的最大含量相关联。还对从其他各种来源培育的黄花蒿植株进行了青蒿素含量检测。根据我们的结果，这些植株中没有一种含有足够量的青蒿素以证明在技术规模上进行分离是合理的。此外，还对其他蒿属物种进行了测试。我们仅在另一个物种中发现了青蒿素。为了可能在植物生长期间增加青蒿素的量，我们在黄花蒿811品系上测试了两种激素型生长调节剂。结果表明，其中一种，矮壮素，能够使青蒿素含量比未处理的植株增加30%。我们还发现生长调节剂对腺毛的形态学标准有一些轻微影响。
