Kaboutari Jahangir, Arab Hossien Ali, Ebrahimi Kambiz, Rahbari Sadegh
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran.
Trop Anim Health Prod. 2014 Jan;46(1):43-8. doi: 10.1007/s11250-013-0444-x. Epub 2013 Jul 19.
Coccidiosis is an important parasitic disease in poultry industry. Owing to the development of drug resistance against Eimeria and concerns about drug residues, attentions toward the alternative compounds including herbal medicines have been increased. This study aimed to examine the prophylactic and therapeutic effects of a new formulation derived from Artemisia sieberi extract on avian coccidiosis.
The extract was obtained from A. sieberi using petroleum ether, and then, it was formulated into a wet granule. Three hundred and sixty 1-day-old broilers were divided into six groups, each with three replicates (n = 20); the first group was chosen as the noninfected control group and the remainders were challenged by oral administration of 250,000 oocysts of Eimeria tenella per chick on day 21. Group 2 (as nontreated control) received no treatment, but group 3 (as prophylactic group) received 0.5 mg/kg artemisinin 10 days before challenging with E. tenella. However, groups 4, 5, and 6 received 1 mg/kg artemisinin on the next day and at 24 and 48 h after the challenge, respectively, for 5 days. Mortality rate, bloody diarrhea score, lesion score, and oocysts per gram (OPG) of feces were used to determine the anticoccidial effects of the formulation.
The granule significantly (p < 0.05) reduced mortality, diarrhea, and lesion score in the treated groups. The OPG output was also significantly (p < 0.0001) reduced in the groups that received formulation. However, there was no significant difference between the prophylactic and therapeutic groups.
The results suggested that this new formulation is a promising herbal medicine that can be used as a prophylactic or therapeutic product to control avian coccidiosis.
球虫病是家禽业中一种重要的寄生虫病。由于对艾美耳球虫产生耐药性以及对药物残留的担忧，人们对包括草药在内的替代化合物的关注度有所增加。本研究旨在考察一种从西伯利亚艾蒿提取物衍生而来的新制剂对禽球虫病的预防和治疗效果。
用石油醚从西伯利亚艾蒿中提取提取物，然后将其制成湿颗粒。360只1日龄肉鸡分为6组，每组3个重复（n = 20）；第一组作为未感染对照组，其余组在第21天每只鸡口服250,000个柔嫩艾美耳球虫卵囊进行攻毒。第2组（作为未处理对照组）不进行处理，但第3组（作为预防组）在攻毒前10天接受0.5mg/kg青蒿素。然而，第4、5和6组分别在攻毒后第2天、24小时和48小时接受1mg/kg青蒿素，持续5天。用死亡率、血便评分、病变评分和每克粪便中的卵囊数（OPG）来确定该制剂的抗球虫效果。
该颗粒显著（p < < span="">0.05）降低了治疗组的死亡率、腹泻和病变评分。接受该制剂的组中OPG产量也显著（p < < span="">0.0001）降低。然而，预防组和治疗组之间没有显著差异。
结果表明，这种新制剂是一种有前景的草药，可作为预防或治疗产品用于控制禽球虫病。
