Coremans I E, Daha M R, van der Voort E A, Muizert Y, Halma C, Breedveld F C
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Clin Exp Immunol. 1992 Feb;87(2):256-60. doi: 10.1111/j.1365-2249.1992.tb02984.x.
The prevalence of antibodies against the collagen-like region of the subcomponent of the first component of complement, C1q, was investigated in 11 patients with anti-glomerular basement membrane (GBM) nephritis. Anti-C1q antibodies (anti-C1qAb) were detected in seven patients. IgG anti-C1qAb were found in four and IgA anti-C1qAb in five patients. During follow up of the patients a relationship was observed between the levels of IgG anti-C1qAb and the levels of anti-GBM antibodies (anti-GBMAb). Gelfiltration experiments indicated that both IgG anti-C1qAb as well as IgG anti-GBMAb were monomeric and that binding also occurred with the F(ab')2 fragments of the antibodies. Although anti-C1qAb and anti-GBMAb are both directed against a collagen-like structure, it was demonstrated by means of inhibition experiments that anti-C1qAb and anti-GBMAb are directed against different antigenic sites. Comparison of patients with anti-GBM nephritis with and without anti-C1qAb revealed that there were no differences in disease activity or disease severity. Therefore, the results of this study suggest that anti-C1qAb do not play a direct pathogenetic role in anti-GBM nephritis.
在11例抗肾小球基底膜（GBM）肾炎患者中，研究了针对补体第一成分C1q亚成分的胶原样区域的抗体的流行情况。在7例患者中检测到抗C1q抗体（抗C1qAb）。4例患者发现IgG抗C1qAb，5例患者发现IgA抗C1qAb。在对患者的随访中，观察到IgG抗C1qAb水平与抗GBM抗体（抗GBMAb）水平之间存在关联。凝胶过滤实验表明，IgG抗C1qAb以及IgG抗GBMAb均为单体，并且抗体的F(ab')2片段也会发生结合。尽管抗C1qAb和抗GBMAb均针对胶原样结构，但通过抑制实验证明，抗C1qAb和抗GBMAb针对不同的抗原位点。对有和没有抗C1qAb的抗GBM肾炎患者进行比较发现，疾病活动度或疾病严重程度没有差异。因此，本研究结果表明，抗C1qAb在抗GBM肾炎中不发挥直接的致病作用。
